The green algal carotenoid siphonaxanthin inhibits adipogenesis in 3T3-L1 preadipocytes and the accumulation of lipids in white adipose tissue of KK-Ay mice

The Journal of Nutrition
Zhuo-Si LiTatsuya Sugawara

Abstract

Siphonaxanthin, a xanthophyll present in green algae, has been shown to possess antiangiogenic and apoptosis-inducing activities. We evaluated the antiobesity effects of siphonaxanthin by using a 3T3-L1 cell culture system and in diabetic KK-Ay mice. 3T3-L1 cells were differentiated with or without 5 μmol/L siphonaxanthin, and lipid accumulation and critical gene expressions for adipogenesis were examined. In vivo, 4-wk-old male KK-Ay mice were administered daily oral treatment of 1.3 mg siphonaxanthin for 6 wk and body weight, visceral fat weight, serum variables, and gene expressions involved in lipid metabolism were evaluated. Compared with the other carotenoids evaluated, siphonaxanthin potently inhibited adipocyte differentiation. Siphonaxanthin significantly suppressed lipid accumulation at noncytotoxic concentrations of 2.5 and 5 μmol/L by 29% and 43%, respectively. The effects of siphonaxanthin were largely limited to the early stages of adipogenesis. Siphonaxanthin significantly inhibited protein kinase B phosphorylation by 48% and 72% at 90 and 120 min, respectively. The expressions of key adipogenesis genes, including CCAAT/enhancer binding protein α (Cebpa), peroxisome proliferator activated receptor γ (Pparg), fatt...Continue Reading

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Citations

Nov 26, 2015·Journal of Ethnopharmacology·M SaravananS Ignacimuthu
Jan 18, 2019·Journal of Oleo Science·Yuki ManabeTatsuya Sugawara
Oct 2, 2019·Lipids·Yuki ManabeTatsuya Sugawara
Feb 23, 2020·Marine Drugs·Noémie CoulombierNicolas Lebouvier
Jun 5, 2020·Marine Drugs·Zhuosi LiTatsuya Sugawara
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Nov 2, 2018·Journal of Nutritional Science and Vitaminology·Zhuo-Si LiTatsuya Sugawara
Dec 13, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Yeon-Seop JungSyng-Ook Lee
Jan 21, 2021·Marine Drugs·Clementina SansoneChristophe Brunet
Mar 3, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·M Luisa BonetAndreu Palou
Jun 9, 2021·Journal of Microbiology and Biotechnology·Sung-Gyu Lee, Hyun Kang

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