The ground state of embryonic stem cell self-renewal

Nature
Qi-Long YingAustin G Smith

Abstract

In the three decades since pluripotent mouse embryonic stem (ES) cells were first described they have been derived and maintained by using various empirical combinations of feeder cells, conditioned media, cytokines, growth factors, hormones, fetal calf serum, and serum extracts. Consequently ES-cell self-renewal is generally considered to be dependent on multifactorial stimulation of dedicated transcriptional circuitries, pre-eminent among which is the activation of STAT3 by cytokines (ref. 8). Here we show, however, that extrinsic stimuli are dispensable for the derivation, propagation and pluripotency of ES cells. Self-renewal is enabled by the elimination of differentiation-inducing signalling from mitogen-activated protein kinase. Additional inhibition of glycogen synthase kinase 3 consolidates biosynthetic capacity and suppresses residual differentiation. Complete bypass of cytokine signalling is confirmed by isolating ES cells genetically devoid of STAT3. These findings reveal that ES cells have an innate programme for self-replication that does not require extrinsic instruction. This property may account for their latent tumorigenicity. The delineation of minimal requirements for self-renewal now provides a defined plat...Continue Reading

References

Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TakedaS Akira
Sep 11, 2002·Trends in Cell Biology·Tom BurdonPierre Savatier
Sep 27, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mia Buehr, Austin Smith
Dec 31, 2003·Methods in Enzymology·Qi-Long Ying, Austin G Smith
May 19, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kazuya OgawaHitoshi Niwa
Sep 21, 2004·Oncogene·Ian Chambers, Austin Smith
Jan 28, 2005·Development·Peter CartwrightStephen Dalton
Sep 20, 2005·Nature·Alejandro Colman-LernerRoger Brent
Dec 22, 2005·Nature Reviews. Genetics·Alfonso Martinez Arias, Penelope Hayward
Mar 15, 2006·Biochemical and Biophysical Research Communications·Kazuya OgawaHitoshi Niwa
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shuibing ChenSheng Ding
Sep 14, 2007·The Biochemical Journal·Jenny BainPhilip Cohen

Citations

Jan 6, 2010·EMBO Molecular Medicine·Austin G Smith
Apr 8, 2010·EMBO Molecular Medicine·Austin G Smith
Oct 17, 2012·Cellular and Molecular Life Sciences : CMLS·Michele BertacchiFederico Cremisi
May 16, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mehdi PirouzMichael Kessel
Jul 9, 2009·Cell and Tissue Research·Shinkichi Ishikawa, Kazuo Ito
Mar 31, 2011·Molecules and Cells·Sungtae Kim, Juan Carlos Izpisúa Belmonte
Feb 19, 2011·Journal of Mammary Gland Biology and Neoplasia·Ewa M Michalak, Jos Jonkers
Oct 18, 2011·Transgenic Research·Satoshi YamamotoTadatoshi Hashimoto
Aug 10, 2012·Transgenic Research·Masumi HirabayashiShinichi Hochi
Dec 25, 2009·In Vitro Cellular & Developmental Biology. Animal·Yohei HayashiMakoto Asashima
Jan 28, 2012·In Vitro Cellular & Developmental Biology. Animal·Haruka HiroseAkihiko Taguchi
Feb 25, 2011·Stem Cell Reviews and Reports·Kristina NagyAndras Nagy
May 4, 2011·Stem Cell Reviews and Reports·Marie-Emmanuelle MathieuHélène Bœuf
May 23, 2012·Molecular Neurobiology·Aisha Iman AbdullahTao Sun
Aug 14, 2013·Journal of Biosciences·Carlos Sonnenschein, Ana M Soto
Feb 17, 2010·International Journal of Hematology·Shinji Masui
Mar 1, 2012·Archives of Pharmacal Research·Yongmun Choi, Tae-Gyu Nam
Aug 27, 2013·Analytical Biochemistry·Kenichiro DonaiTomokazu Fukuda
Feb 20, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Alexis M Temkin, Demetri D Spyropoulos
Oct 9, 2012·Cell Reports·Samantha A MorrisMagdalena Zernicka-Goetz
Oct 1, 2013·Genomics, Proteomics & Bioinformatics·Guangjun XiQi-Long Ying
Nov 28, 2012·Stem Cell Research·Diana CoronadoPierre Savatier
Jan 9, 2009·Cell Stem Cell·Sachin Malhotra, Paul W Kincade
May 12, 2009·Cell Stem Cell·Tariq EnverPeter W Andrews
Sep 2, 2010·Cell Stem Cell·Jian YangAustin G Smith
Nov 3, 2010·Cell Stem Cell·Christa Buecker, Niels Geijsen
Dec 12, 2012·Cell Stem Cell·Naoki Oshimori, Elaine Fuchs
Sep 21, 2013·Stem Cell Reports·Harry G LeitchAustin G Smith
May 21, 2013·Trends in Cell Biology·Maaike Welling, Niels Geijsen
Mar 4, 2014·Methods : a Companion to Methods in Enzymology·Séverine MénoretIgnacio Anegon
Mar 20, 2009·Quarterly Reviews of Biophysics·Louise N Johnson
Jan 6, 2010·Journal of Medicinal Chemistry·Agnès I LukaszewiczMichael Kahn
May 7, 2013·Acta Pharmacologica Sinica·Bi WuXiao-Yang Zhao
Jun 4, 2013·Acta Pharmacologica Sinica·Jian-bin SuBaoming Qin
Jun 29, 2013·Cell Death & Disease·J-I HanaiV P Sukhatme
Feb 3, 2009·Cell Research·Duanqing Pei
Aug 4, 2009·Cell Research·Anton Wutz
Aug 31, 2011·Cell Research·Felipe De Sousa E Melo, Jan Paul Medema
Jun 15, 2011·Cell Research·Yan ShenHongkui Deng
Dec 12, 2012·Cell Research·Jia-Chi Yeo, Huck-Hui Ng
Dec 26, 2012·Cell Research·Wenlin LiSheng Ding
Aug 28, 2013·Cell Research·Alejandro De Los Angeles, George Q Daley
Sep 9, 2011·Nature·Martin Leeb, Anton Wutz
Jun 23, 2012·Nature·Todd S MacfarlanSamuel L Pfaff
May 5, 2011·Nature Cell Biology·Huck-Hui Ng, M Azim Surani
Aug 3, 2011·Nature Cell Biology·Noa Novershtern, Jacob H Hanna
Sep 6, 2011·Nature Cell Biology·Hitoshi Niwa
Oct 30, 2012·Nature Cell Biology·Ben D MacArthurIhor R Lemischka
Jun 7, 2013·Nature Communications·Tomokazu AmanoMinoru S H Ko
Jul 19, 2013·Nature Communications·Feng ZhouJarrod A Marto
Jun 6, 2009·Nature Medicine·Jennifer NicholsAnne Cooke
Aug 13, 2013·Nature Methods·Clinton H Hansen, Alexander van Oudenaarden
Mar 13, 2010·Nature Protocols·Angel RayaJuan Carlos Izpisúa Belmonte
Jul 13, 2013·Nature Protocols·Katsuhiko Hayashi, Mitinori Saitou
Sep 10, 2009·Nature Reviews. Molecular Cell Biology·Ben D MacArthurIhor R Lemischka
Jan 22, 2011·Nature Reviews. Molecular Cell Biology·Chris JoplingJuan Carlos Izpisúa Belmonte
Feb 7, 2012·Nature Structural & Molecular Biology·Myoung Ok KimZigang Dong
Feb 19, 2013·Nature Structural & Molecular Biology·Harry G LeitchPetra Hajkova
Mar 7, 2013·Nature Structural & Molecular Biology·Christoph Bock, Anton Wutz
Jul 4, 2012·Oncogene·K KobayashiS-I Nishikawa
Sep 21, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Xinyue Zhang, Jing Huang
Sep 20, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kento OnishiPeter W Zandstra
Sep 24, 2013·Molecular BioSystems·Bruno César Feltes, Diego Bonatto
Jan 21, 2009·Reproduction, Fertility, and Development·Tetsuya S Tanaka
Sep 7, 2012·Reproduction, Fertility, and Development·Maryam PashaiaslPaul J Verma
Dec 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianchang YangYupo Ma
Mar 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lena HoGerald R Crabtree
May 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Costas A LyssiotisRudolf Jaenisch
May 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro SekiMakoto Asashima
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Po-Min ChiangPhilip C Wong
May 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacob H HannaRudolf Jaenisch
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Masaki Kawamata, Takahiro Ochiya
Oct 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Wei WangPentao Liu
Jan 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Laralynne M Przybyla, Joel Voldman
Oct 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jaclyn G Y Lim, Margaret T Fuller
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anna N MelidoniJohn McCafferty
Aug 14, 2010·The Journal of Biological Chemistry·Hongyan ZhouSheng Ding
Dec 22, 2009·The Journal of Biological Chemistry·Daniel C KraushaarLianchun Wang
Apr 30, 2010·The Journal of Biological Chemistry·Katherine E GalvinJay L Vivian
Feb 3, 2012·The Journal of Biological Chemistry·Maud ForsbergKarin Forsberg-Nilsson
Sep 15, 2012·The Journal of Biological Chemistry·Zhaoting WuLingyi Chen
Sep 8, 2012·The Journal of Biological Chemistry·Go NagamatsuToshio Suda
Feb 27, 2013·The Journal of Biological Chemistry·Yongyu XuXin Xie
Dec 7, 2011·The Journal of Experimental Medicine·Bart A WestermanMaarten van Lohuizen
Jan 5, 2011·Antioxidants & Redox Signaling·Ji Woong Han, Young-Sup Yoon
Feb 6, 2010·Cellular Reprogramming·Yu-Qiang Li
Oct 13, 2010·Cellular Reprogramming·Maryam PashaiaslPaul J Verma
Jun 12, 2010·Stem Cells and Development·Fatima A SalehPaul G Genever
May 19, 2012·Stem Cells and Development·Lan T H DangVincent Tropepe
Feb 22, 2012·Stem Cells and Development·Jared M CampbellMichelle Lane
May 9, 2012·Stem Cells and Development·Toshihiro KobayashiHiromitsu Nakauchi
Sep 22, 2012·Stem Cells and Development·Nadejda V MezentsevaLeonard M Eisenberg
Jan 4, 2013·Stem Cells and Development·V VermaBjörn Oback
May 14, 2011·Zebrafish·Vanesa RoblesJuan Carlos Izpisúa Belmonte
Apr 21, 2009·British Medical Bulletin·M William Lensch
Oct 28, 2009·Carcinogenesis·C MaenhautW C G van Staveren
Aug 12, 2008·Human Molecular Genetics·Sophie ThomasHeather C Etchevers
Aug 14, 2010·Human Reproduction Update·Ewart KuijkBernard A J Roelen
Jun 9, 2009·Journal of Molecular Cell Biology·Zhao WuLei Xiao
Dec 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi-Chin Toh, Joel Voldman
May 7, 2011·Current Opinion in Nephrology and Hypertension·Guanyi HuangQi-Long Ying
Oct 12, 2012·Journal of the Royal Society, Interface·Yang LuoLorenz Wernisch
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thorold W Theunissen, José C R Silva
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kun XueHuck-Hui Ng
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jem A Efe, Sheng Ding
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rodrigo Osorno, Ian Chambers
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ian WilmutIan Chambers
Feb 10, 2012·Cold Spring Harbor Perspectives in Biology·Dennis van HoofChristine Mummery
Jul 4, 2012·Genes & Development·Julien Sage
Oct 19, 2010·Genes & Development·Matthias Stadtfeld, Konrad Hochedlinger
Jun 22, 2013·Genes & Development·Philipp VoigtDanny Reinberg
Mar 31, 2009·Cold Spring Harbor Symposia on Quantitative Biology·Ben D MacArthurIhor R Lemischka
Jan 19, 2010·Development, Growth & Differentiation·Norito ShibataKiyokazu Agata
Jan 19, 2010·Development, Growth & Differentiation·Keiichi KatsumotoShoen Kume
Feb 13, 2010·Development, Growth & Differentiation·Hitoshi Niwa
Mar 20, 2010·Development, Growth & Differentiation·Kazutoshi Takahashi
Mar 23, 2013·Science·Shukry J HabibRoel Nusse
Apr 1, 2011·Science Translational Medicine·Wenlin Li, Sheng Ding
Feb 19, 2009·Molecular and Cellular Biology·Matthew Bechard, Stephen Dalton
May 15, 2013·Annual Review of Genomics and Human Genetics·Derek LessingJeannie T Lee
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Shenghui HeSean J Morrison
Apr 22, 2011·Cancer Research·Carlos Sonnenschein, Ana M Soto
Dec 5, 2009·The Journal of Clinical Investigation·Jian HuangPeter S Klein
Sep 22, 2012·Journal of Translational Medicine·Xinrong PengMengchao Wu
Dec 7, 2013·Epigenetics & Chromatin·Martin Leeb, Anton Wutz
Mar 16, 2012·Endocrine Reviews·Laura N VandenbergJohn Peterson Myers
Jan 27, 2009·Development·Konrad Hochedlinger, Kathrin Plath
Mar 13, 2009·Development·Ludovic VallierRoger Pedersen
Oct 28, 2010·Development·Karel Dorey, Enrique Amaya
Aug 28, 2009·Development·Jennifer NicholsAustin G Smith
Feb 10, 2012·Development·Kathy K NiakanRenee A Reijo Pera
Aug 23, 2012·Development·Martin LeebAnton Wutz
Jun 23, 2011·RNA·Chao-Shun YangTariq M Rana
Nov 5, 2011·The Journal of Reproduction and Development·Akifumi KandaEiso Hiyama
Feb 1, 2013·The Journal of Reproduction and Development·Mami OikawaAtsuo Ogura
Oct 9, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Christoffer TammJin-Ping Li
Oct 24, 2008·PLoS Biology·Jose SilvaAustin G Smith
Dec 29, 2010·PLoS Computational Biology·Florian MarkowetzOlga G Troyanskaya
Jul 23, 2013·PLoS Computational Biology·Jincheng Wu, Emmanuel S Tzanakakis
Apr 15, 2011·PLoS Genetics·Kathryn BlairAustin G Smith
Mar 8, 2013·PLoS Genetics·Giulia FragolaGiuseppe Testa
Apr 12, 2014·PLoS Genetics·Johann de JongJeroen de Ridder
Jan 7, 2011·PloS One·Bruno Di StefanoVania Broccoli
Jul 27, 2011·PloS One·Sanae HamanakaHiromitsu Nakauchi
Jun 8, 2012·PloS One·Devanand S ManoliNirao M Shah
Jul 31, 2012·PloS One·Federico FerroFrancesco Curcio
Nov 13, 2012·PloS One·Aida RodríguezRamiro Alberio
Dec 18, 2013·PloS One·Christoffer TammCecilia Annerén
Jan 28, 2014·PloS One·Angelo RaggioliRolf Kemler
Mar 20, 2014·PloS One·Maria HerbergIngo Roeder
Feb 2, 2013·Biological Chemistry·Daniel C KraushaarLianchun Wang
Jul 24, 2012·Journal of Molecular Endocrinology·Clara V AlvarezSusana B Bravo
Jan 1, 2012·The Review of Diabetic Studies : RDS·John P DriverClayton E Mathews
Sep 16, 2011·Regenerative Medicine·Bahram ValamehrHong Wu
Nov 20, 2009·Journal of Visualized Experiments : JoVE·Wen XiongYang Liu
Sep 3, 2011·Future Medicinal Chemistry·Paul D Andrews
May 25, 2011·World Journal of Stem Cells·Jean-Marie RamirezJohn De Vos
Jan 10, 2014·Nature Communications·Yongshun LinStephen J Weiss
Jan 31, 2014·Nature·Haruko ObokataCharles A Vacanti
Feb 1, 2014·Transgenic Research·Susanna KautschitschThomas Rülicke
Apr 30, 2015·Stem Cells International·Tongxiang Lin, Shouhai Wu
Mar 15, 2014·Nature Protocols·Zoltán IvicsZsuzsanna Izsvák
Dec 12, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Néstor Saiz, Berenika Plusa
Feb 7, 2014·Stem Cell Research & Therapy·Ling Shuai, Qi Zhou
Oct 24, 2013·Stem Cells and Development·Seyedeh-Nafiseh HassaniHossein Baharvand
Apr 22, 2014·Nature Materials·Stefano PagliaraKevin Chalut
Feb 26, 2014·Stem Cells and Development·Morteza JalaliLudovic Vallier
Jul 19, 2012·Zygote : the Biology of Gametes and Early Embryos·Yan ZhuMan-Xi Jiang
Mar 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Carol B WareHannele Ruohola-Baker
Dec 29, 2013·Nucleic Acids Research·Katharina ThanischHeinrich Leonhardt
May 17, 2014·Cell Death & Disease·Kai LiuT Zhao
Apr 2, 2014·Molecular Brain·Hideyuki Okano, Shinya Yamanaka
May 3, 2014·Nature Protocols·Karl R Koehler, Eri Hashino
May 31, 2014·Nature Cell Biology·Berenika Plusa, Anna-Katerina Hadjantonakis
Apr 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Senthilkumar CinghuRaja Jothi
Feb 14, 2014·Molecular Biology of the Cell·Yuxuan GuoYixian Zheng
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Frederick E Tan, Michael B Elowitz
Mar 20, 2014·Cellular and Molecular Life Sciences : CMLS·Giuseppe LupoFederico Cremisi
Aug 28, 2014·Regenerative Medicine·Carol B Ware
Oct 5, 2011·Stem Cells International·Massimo De Felici
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sen WuMario R Capecchi
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Jane Lynda Deuve, Philip Avner
Sep 16, 2014·Nature Communications·Martina TholenThomas Reinheckel
Aug 2, 2011·Annual Review of Genomics and Human Genetics·Yuin-Han LohGeorge Q Daley
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Graziano Martello, Austin G Smith
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stéphanie Hermitte, Claire Chazaud
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tuzer Kalkan, Austin G Smith
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thorsten Boroviak, Jennifer Nichols
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David-Emlyn Parfitt, Michael M Shen
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sophie M Morgani, Joshua M Brickman
Nov 21, 2014·Nature Chemistry·Martin BachmanShankar Balasubramanian
Mar 15, 2013·Development·Jackson A HoffmanBradley J Merrill
Jan 1, 2012·Cell Regeneration·Jolene Ooi, Pentao Liu
Nov 14, 2015·Annual Review of Animal Biosciences·Toshihiko EzashiR Michael Roberts
Nov 25, 2015·Expert Opinion on Therapeutic Patents·Muhammad Ayaz AnwarSangdun Choi
Jun 10, 2010·Expert Opinion on Biological Therapy·Axel SchambachToni Cathomen
Feb 11, 2016·Nature Reviews. Molecular Cell Biology·Leehee WeinbergerJacob H Hanna
Jan 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Malkiel A CohenRudolf Jaenisch
Oct 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Haixia ChenLingyi Chen
Sep 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Masahiro HachisugaChikara Meno
Feb 18, 2016·Nature Reviews. Molecular Cell Biology·Kazutoshi Takahashi, Shinya Yamanaka
Feb 4, 2016·Stem Cells International·Alexandra J HarveyDavid K Gardner
Jan 23, 2016·Stem Cells International·Luca FagnocchiAlessio Zippo
Jan 23, 2016·Stem Cells International·Antonio Romito, Gilda Cobellis
Jan 21, 2016·Stem Cells International·Yan-Chuang HanXin-Fu Zhou
Dec 17, 2015·Scientific Reports·Sara TaleahmadGhasem Hosseini Salekdeh
Nov 19, 2015·Cellular Reprogramming·Fuliang DuJie Xu
Jan 16, 2016·Stem Cells International·Clair E WeidgangMartin Mueller
Nov 28, 2015·Nature Cell Biology·Jun Wu, Juan Carlos Izpisúa Belmonte
Dec 15, 2015·Frontiers in Veterinary Science·Dean H Betts, Ian C Tobias
Jun 21, 2015·Nucleic Acids Research·Hiroshi OchiaiTakashi Yamamoto
Oct 10, 2013·Molecular Systems Biology·Silvia Muñoz DescalzoAlfonso Martinez Arias
Mar 10, 2010·Molecular Systems Biology·Daria OnichtchoukWolfgang Driever
Aug 8, 2015·Science·Jonathan P LingPhilip C Wong
Feb 9, 2010·Cell Biology International·Sakiko MiyazuMamoru Nakanishi
Aug 27, 2015·Cellular and Molecular Life Sciences : CMLS·Nora Bengoa-Vergniory, Robert M Kypta
Oct 16, 2015·The Journal of Cell Biology·Sujash S ChatterjeeRamanuj DasGupta
May 1, 2015·Cell Cycle·Mehdi PirouzMichael Kessel
Sep 2, 2015·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Tomohiko AkiyamaMinoru S H Ko
Nov 14, 2015·Annual Review of Cell and Developmental Biology·Stefan Semrau, Alexander van Oudenaarden
Sep 22, 2015·Nature Cell Biology·Adam FilipczykTimm Schroeder
Sep 30, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mari Ohnuki, Kazutoshi Takahashi
Aug 4, 2015·Nature Biotechnology·Jérome ChalOlivier Pourquié
Jul 29, 2011·The Biochemical Journal·Hiroyuki HiraiNobuaki Kikyo
Mar 25, 2011·Biochemical Society Transactions·Melanie J WelhamHeather Bone
Jan 27, 2011·Biochemical Society Transactions·Raymond A A SmithCatherine L R Merry
Jan 7, 2015·Genes & Development·Thais LavagnolliMatthias Merkenschlager
May 24, 2013·Biochemical Society Transactions·Kirsten McEwenPetra Hajkova
Jul 21, 2015·Nature Cell Biology·Taka-aki K NoguchiAkira Kurisaki
Nov 26, 2010·Bioscience Reports·Yun Hwa Lee, Qiang Wu
May 24, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Josephine KuglerMichael Oelgeschläger
Jun 23, 2015·Nature Chemical Biology·Martin BachmanShankar Balasubramanian
Dec 5, 2014·Nature·Roshan M KumarJames J Collins
Feb 2, 2013·Biological & Pharmaceutical Bulletin·Yoko Nakai-Futatsugi, Hitoshi Niwa
Jun 26, 2015·Scientific Data·Munazah AndrabiNick R Love
May 20, 2015·Nature Cell Biology·Yasong WuDuanqing Pei
May 30, 2015·Retrovirology·Luisa Robbez-Masson, Helen M Rowe
May 7, 2015·Nature·Jun WuJuan Carlos Izpisúa Belmonte
Jun 17, 2014·Oncogene·P-Y Tung, P S Knoepfler
Jan 29, 2014·JAK-STAT·Yong Tang, Xiuchun Cindy Tian
Jan 18, 2013·Nucleus·Melanie A Eckersley-MaslinDavid L Spector
Jul 1, 2012·JAK-STAT·Marc Amoyel, Erika A Bach
Mar 9, 2011·Cell Cycle·Guanyi HuangQi-Long Ying
Sep 26, 2014·Worm·Jianhao JiangGyörgyi Csankovszki
Mar 31, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Zhiwei NiuJinlian Hua
Feb 7, 2015·Science·Hendrik G StunnenbergYaser Atlasi
Apr 23, 2013·Nature Cell Biology·Raedun L ClarkeGordon Keller
Mar 13, 2015·Frontiers in Cellular Neuroscience·Leticia PereiraEsther Pozas
Oct 18, 2014·Frontiers in Oncology·Javier A Menendez, Tomás Alarcón
Sep 24, 2014·Stem Cells and Development·Sabitri GhimireP De Sutter
Jun 21, 2014·Nucleic Acids Research·Udo MüllerHeinrich Leonhardt
Aug 4, 2015·Genome Biology·Hendrik MarksHendrik G Stunnenberg
Jan 20, 2015·Nature Cell Biology·Fiona K BangsKathryn V Anderson
Sep 12, 2014·Stem Cells and Development·Young Tae HeoJongpil Kim
Jan 23, 2015·Stem Cells International·Rui DaiErich D Jarvis
May 11, 2016·Nature Communications·Shingo MiyawakiKyoko Miura
May 20, 2016·Cell Death & Disease·L RinaldiA Feliciello
Jun 3, 2016·Cellular Reprogramming·Yasumasa ShirouzuShoichiro Sumi
Jun 11, 2016·Acta Biotheoretica·Mariano Bizzarri, Alessandra Cucina
May 22, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Josephine KuglerMichael Oelgeschläger
May 26, 2016·Stem Cells and Development·María Concepción Cruz-SantosAlfredo Cruz-Ramírez
Jul 10, 2016·Stem Cells and Development·Ian C TobiasDean H Betts
Jul 29, 2016·Human Molecular Genetics·Haoyu WuLucia Daxinger
Aug 31, 2016·Nature Reviews. Genetics·Walfred W C TangM Azim Surani
Aug 9, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Sonja E GustinPatrick S Western
Oct 11, 2016·ELife·Robert S IllingworthJoshua M Brickman
Oct 19, 2016·Cell Cycle·Javier PrietoJosema Torres
Nov 9, 2016·The Journal of Cell Biology·Bryne UlmschneiderTodd G Nystul
Nov 12, 2016·Cell Death and Differentiation·Zhenqing LiuHsiao-Chang Chan
Jan 4, 2017·Nature Reviews. Genetics·Mo Li, Juan Carlos Izpisua Belmonte
Feb 14, 2017·Nature Cell Biology·Lijun LiuPiotr Sicinski
Mar 21, 2017·Genes & Development·Ng Shyh-Chang, Huck-Hui Ng
Dec 9, 2015·Cold Spring Harbor Symposia on Quantitative Biology·Kazuki Kurimoto, Mitinori Saitou
Nov 20, 2015·Cold Spring Harbor Symposia on Quantitative Biology·Kevin Andrew Uy Gonzales, Huck-Hui Ng
Oct 21, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peng YangTodd S Macfarlan
Apr 22, 2017·Nature Communications·S WarrierB Heindryckx
Apr 16, 2017·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ying YanYangming Wang
Jan 4, 2017·The Journal of Cell Biology·Oguzhan Atay, Jan M Skotheim
Oct 16, 2013·Scientific Reports·Masaki ShigetaHitoshi Niwa
Mar 24, 2016·Cell Regeneration·Young Jin LeeKye-Seong Kim
Apr 4, 2017·Cell Stem Cell·Jiho ChoiKonrad Hochedlinger
May 7, 2016·Cell Stem Cell·Jonathan A BeaganJennifer E Phillips-Cremins
Oct 13, 2016·Cell Reports·Eric O WilliamsLeonard Guarente
May 16, 2017·Nature Genetics·Rita KhoueiryKian Peng Koh
Jun 4, 2016·Cell Stem Cell·Mitinori Saitou, Hidetaka Miyauchi
May 11, 2017·Genes & Development·Kaixiang CaoAli Shilatifard
Feb 20, 2017·Journal of Molecular Biology·Christina AmbrosiTuncay Baubec
Jan 26, 2017·Journal of Molecular Biology·Maxime BodakConstance Ciaudo
Dec 19, 2016·Journal of Molecular Biology·Nicola FestucciaPablo Navarro
May 23, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rika TeshigawaraTakashi Tada
Dec 26, 2016·Journal of Molecular Biology·Joerg Betschinger
Jun 3, 2017·Cell Stem Cell·Peter Karagiannis, Yasuhiro Takashima
Oct 16, 2016·Stem Cells·Agata StryjewskaDanny Huylebroeck
Jun 8, 2017·Stem Cell Reports·Jamie A HackettM Azim Surani
Jun 23, 2009·Stem Cells·Esther CampJosé L Mullor
Apr 11, 2009·Current Opinion in Genetics & Development·Mareike Albert, Antoine H F M Peters
Sep 10, 2014·Genesis : the Journal of Genetics and Development·Zhaoyu LinJing Zhao
Apr 22, 2014·Nature Methods·Dominic GrünAlexander van Oudenaarden
Mar 19, 2014·Brain Structure & Function·Wei-Fang ChangLi-Ying Sung
Dec 29, 2013·Stem Cell Reports·Jamie A HackettM Azim Surani
Jul 30, 2014·Biotechnology and Bioengineering·Ashley L FritzDavid V Schaffer
May 20, 2014·Cell Stem Cell·Rodrigo L dos SantosJosé C R Silva
Dec 2, 2016·Nature·Jun WuJuan Carlos Izpisua Belmonte
Dec 28, 2016·Biochemical and Biophysical Research Communications·Qiang WeiBaohua Ma
Jan 24, 2017·Cell·Constantinos ChronisKathrin Plath
Dec 28, 2016·PLoS Biology·Mitra MojtahediSui Huang
Feb 7, 2017·Scientific Reports·Nicholas J GenoveseR Michael Roberts
Jun 30, 2015·Stem Cells·Benjamin T DodsworthSally A Cowley
Mar 24, 2017·PloS One·Manabu KawataTaku Saito
Mar 24, 2017·Stem Cell Reports·Ali RahjoueiMichael Kessel
Dec 6, 2016·Molecular BioSystems·M BaranekJ Barciszewski
Feb 22, 2017·Development, Growth & Differentiation·Ayumu SuzukiAkihiko Okuda
Nov 24, 2016·Nature·Aydan Bulut-KarsliogluMiguel Ramalho-Santos
Jan 18, 2017·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yuhei AshidaEisuke Nishida
Apr 5, 2017·Scientific Reports·Styliani KontogeorgakiBen D MacArthur
Mar 7, 2017·Current Stem Cell Reports·Shugo TohyamaKeiichi Fukuda
Jan 1, 2016·Reproduction, Fertility, and Development·R Michael RobertsToshihiko Ezashi
Dec 3, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Joshua M Brickman, Palle Serup
Sep 16, 2015·Biomaterials Science·Christian ManganiMark Bradley
Nov 28, 2016·Trends in Genetics : TIG·Lin Liu
Jul 10, 2014·Development·Elsa AbranchesDomingos Henrique