The Growing Genetic and Functional Diversity of Extended Spectrum Beta-Lactamases

BioMed Research International
Sadeeq Ur RahmanJian Gao

Abstract

The β-lactams-a large class of diverse compounds-due to their excellent safety profile and broad antimicrobial spectrum are considered to be the most widely used therapeutic class of antibacterials prescribed in human and veterinary clinical practices. This, unfortunately, has also given rise to a continuous increased resistance globally in health care settings as well as in the community due to their permanent selective force driving diversification of the resistance mechanism. Resistance against β-lactams is increasing rapidly as novel β-lactamases, enzymes that degrade β-lactams, are being discovered each day such as recent emergence of extended spectrum β-lactamases (ESBL) that have the ability to inactivate most of the cephalosporins. The complexity and diversity of ESBL are increasing so rapidly that more than 170 variants have thus far been described for only a single genotype, the blaCTX-M -encoding ESBL. This review is to organize all the current updated literature describing genomic features, organization, and mechanism of resistance and mode of dissemination of all known ESBLs.

References

Sep 1, 1976·The Journal of Infectious Diseases·W E Farrar, N M O'dell
May 1, 1992·Antimicrobial Agents and Chemotherapy·A SeoaneJ M García Lobo
May 15, 1991·The Biochemical Journal·R P AmblerS G Waley
Jan 1, 1986·The Journal of Antimicrobial Chemotherapy·N A CurtisA J White
May 2, 1986·European Journal of Biochemistry·F Lindberg, S Normark
Nov 1, 1986·The Biochemical Journal·B JorisR Sykes
Oct 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M V HayesS G Amyes
Jan 1, 1996·Antimicrobial Agents and Chemotherapy·A BauernfeindH Giamarellou
Jan 1, 1997·The Journal of Antimicrobial Chemotherapy·O GaillotA Philippon
Jul 1, 1997·The American Journal of Medicine·J D PitoutW E Sanders
Mar 25, 1999·Mayo Clinic Proceedings·A J Wright
Jul 2, 1999·Antimicrobial Agents and Chemotherapy·G A Jacoby, J Tran
Jul 14, 2001·Antimicrobial Agents and Chemotherapy·I Stock, B Wiedemann
Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S B Levy
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·Stuart B Levy
Aug 23, 2002·Journal of Internal Medicine·B Henriques Normark, S Normark
Jan 25, 2003·Diagnostic Microbiology and Infectious Disease·Dilip MathaiUNKNOWN India Antimicrobial Resistance Study Group
Apr 4, 2003·International Journal of Antimicrobial Agents·Milan Cizman
Nov 25, 2003·BMJ : British Medical Journal·Joumana N Samaha-Kfoury, George F Araj
Mar 12, 2004·International Journal of Antimicrobial Agents·C J MundayP M Hawkey
Mar 30, 2004·Antimicrobial Agents and Chemotherapy·Ryuichi NakanoMatsuhisa Inoue
Jan 28, 2005·The New England Journal of Medicine·George A Jacoby, Luisa Silvia Munoz-Price
Sep 17, 2005·Diagnostic Microbiology and Infectious Disease·Yoichi HirakataUNKNOWN SENTRY Asia-Pacific Participants
Apr 22, 2006·Diagnostic Microbiology and Infectious Disease·Marta Fernández VázquezJosé Angel García-Rodríguez
May 23, 2006·International Journal of Antimicrobial Agents·Mohamed Hamed Mohamed Al-AgamyIrith Wiegand

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Citations

Aug 1, 2018·International Journal of Molecular Sciences·Warawan EiamphungpornChanin Nantasenamat
Mar 8, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Golnaz MobasseriKwai Lin Thong
May 3, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Matheus Silva SanchesSergio Paulo Dejato Rocha
Jun 5, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Raoudha DziriNaouel Klibi
Jul 26, 2019·Expert Review of Anti-infective Therapy·Marguerite L Monogue, David P Nicolau
Sep 29, 2019·Water Environment Research : a Research Publication of the Water Environment Federation·Mithoor DivyashreeIndrani Karunasagar
Dec 16, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Golnaz MobasseriCindy Shuan Ju Teh
Feb 7, 2020·Folia Microbiologica·Iqbal NisaAnwar Ali
Jul 28, 2020·International Journal of Molecular Sciences·Giulia De AngelisMario Tumbarello
Oct 9, 2020·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Anna M Lenart-BorońEwelina Jelonkiewicz
Jan 9, 2021·Frontiers in Microbiology·Anahit M SedrakyanRustam I Aminov
Nov 18, 2020·Antimicrobial Agents and Chemotherapy·Christine A PybusDavid E Greenberg
Jan 21, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Golnaz MobasseriCindy Shuan Ju Teh
Jan 17, 2021·Antibiotics·Nikola Puvača, Rosa de Llanos Frutos
Feb 11, 2021·International Journal of Microbiology·Laura MarchettiNora Mestorino
Nov 18, 2020·International Journal of Molecular Sciences·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
May 1, 2021·Antibiotics·Zoi AthanasakopoulouCharalambos Billinis
Mar 3, 2020·The Science of the Total Environment·Yashini NaidooDon A Cowan
Jul 31, 2021·The Science of the Total Environment·Ana Luísa Almeida ReginaVânia Lúcia da Silva

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Methods Mentioned

BETA
acylation

Software Mentioned

ESBL CARBA

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