PMID: 4326249Jun 1, 1971Paper

The growth and persistence of foot-and-mouth disease virus in the bovine mammary gland

The Journal of Hygiene
R BurrowsD Goodridge

Abstract

In animals exposed to foot-and-mouth disease virus by indirect contact, virus was recovered from the blood, milk, pharynx, vagina and rectum for variable periods of time before clinical disease was apparent. Virus instilled into the mammary gland multiplied rapidly and virus concentrations greater than 10(7) p.f.u./ml. were recorded within 8-32 hr., depending on the virus strain and dose inoculated. Virus multiplication was accompanied by clinical signs of mastitis but the classical signs of foot-and-mouth disease did not appear for 52-117 hr. Dissemination of virus from the mammary gland occurred within 4-24 hr. and in some animals samples taken from the pharynx, mouth, nose and vagina contained virus for periods up to 97 hr. before the appearance of vesicular lesions. Virus production in the udder declined with the appearance of virus neutralizing activity in the blood and the milk but persisted in some animals for periods of 3-7 weeks. The ability of foot-and-mouth disease virus to persist in mammary tissue was confirmed by the demonstration of virus multiplication in the udders of immune animals.

References

Dec 1, 1969·The Journal of Hygiene·R F Sellers, J Parker
Aug 15, 1970·The Veterinary Record·R S Hedger, P S Dawson
Aug 14, 1965·The Veterinary Record·P Sutmoller, A Gaggero

❮ Previous
Next ❯

Citations

Jul 16, 2003·Journal of Comparative Pathology·S AlexandersenA J M Garland
Jul 18, 2002·Veterinary Microbiology·G J WellenbergJ T Van Oirschot
Aug 23, 2002·Microbes and Infection·Soren AlexandersenAlex I Donaldson
Aug 1, 1974·The Journal of Hygiene·R BurrowsW G Chapman
Apr 1, 1980·The Journal of Hygiene·M J Corbel, R A Brewer
Mar 1, 1973·The Journal of Hygiene·R F Sellers, A J Forman
Aug 3, 2002·Immunology·Rachael C RigdenKenneth C MCCullough
Jul 21, 2005·New Zealand Veterinary Journal·H J Pharo
Apr 5, 1972·Equine Veterinary Journal·E P GibbsJ M Morris
Jan 1, 1972·Archiv für die gesamte Virusforschung·J W McVicar, P Sutmoller
Mar 4, 2011·Transboundary and Emerging Diseases·J ArztL L Rodriguez
Oct 1, 1981·Journal of Comparative Pathology·R BurrowsD Goodridge
Jan 1, 1984·Journal of Biological Standardization·J S WalkerJ G van Bekkum
Jul 21, 2004·Journal of Dairy Science·P M Tomasula, R P Konstance
Feb 12, 2019·Transboundary and Emerging Diseases·Bryony ArmsonTiziana Lembo
Dec 6, 2006·American Journal of Veterinary Research·Mark C Thurmond, Andrés M Perez
Jun 13, 2012·Microbiology and Molecular Biology Reviews : MMBR·Esteban DomingoCelia Perales
Mar 24, 2017·Risk Analysis : an Official Publication of the Society for Risk Analysis·A MeyerT Vergne
Jan 22, 2020·Transboundary and Emerging Diseases·Bryony ArmsonNicholas A Lyons
Jun 17, 2020·Frontiers in Veterinary Science·Bryony ArmsonNicholas A Lyons
Jun 18, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Marcel SuchowskiReiner Ulrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.