The growth and pluripotency of mesenchymal stem cell on the biodegradable polyurethane synthesized with ferric catalyst

Journal of Biomaterials Science. Polymer Edition
Qianqian WeiYabin Zhu

Abstract

Polyurethane (PU) is a class of polymers that have been applied for tissue-engineering scaffolds. Cross-linked poly(ester urethane) (CPU), synthesized with ferric catalyst in our laboratory, was modified by silk fibroin (SF) grafting using our aminolysis and glutaradehyde crosslinking method. The physical and chemical properties of the materials were investigated by scanning electron microscope (SEM), atomic force microscope (AFM) and tensile tester. The results showed that SF grafted CPU possessed good strain and strength (4.29 ± 0.18 MPa/382.38 ± 0.71%). Its surface chemistry and roughness were fine to well support the growth of bone marrow mesenchymal stem cells (BMSC). The cells were verified to maintain the pluripotency after they were cultured in vitro for 2 weeks, which supplied us a good technology to keep cell's stemness but proliferate cell's number. These results are valuable for us to further study esophageal tissue engineering with BMSC and polyurethane materials as the components.

References

Sep 19, 2006·Biomaterials·Ian C BonzaniMolly M Stevens
Jul 3, 2013·ACS Applied Materials & Interfaces·Changfeng GongLin Luo
Oct 24, 2013·Journal of Materials Science. Materials in Medicine·Yu-Na LeiLin-Xi Hou
Jun 6, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Sandeep M NalluriDebanjan Sarkar
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Aug 4, 2016·Journal of Biomaterials Science. Polymer Edition·Zhong-Kui LiSi-Ming Yan
Sep 7, 2016·BioMed Research International·Shishu HuangNoureddine Abidi

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Methods Mentioned

BETA
PCR
aminolysis
AFM

Software Mentioned

SF
CPU
NH
Instron

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