PMID: 11328410May 1, 2001Paper

The growth factor receptors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early stage (FIGO I-II) epithelial ovarian carcinoma

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
I SkírnisdóttirT Seidal

Abstract

Epithelial ovarian cancer is a heterogeneous disease and many biologic and molecular factors are important for its development and progression, including growth rate, metastatic potential, chemo- and radiosensitivity, and prognosis. Even in the early stages (FIGO I-II), many questions persist about the biologic behavior, optimal treatment, and prognosis. In a series of 106 patients with epithelial ovarian cancers in FIGO stages IA-IIC, a number of known prognostic factors (age, FIGO stage, histopathologic type, and tumor grade) were studied in relation to two important growth factor receptors for oncogenesis (HER-2/neu and EGFR). Immunohistochemical techniques were used. All patients received adjuvant radiotherapy 4-6 weeks after the primary surgery. In a univariate analysis, the expression of the HER-2/neu receptor was not associated with any of the clinicopathologic factors studied or survival status. Positive EGFR staining was associated with poor survival in a univariate analysis. Co-expression of HER-2/neu and EGFR was most frequently seen in serous tumors and positive staining for HER-2/neu alone was associated with mucinous tumors. Both endometrioid and clear cell tumors belonged to the largest subgroup with concomitant ...Continue Reading

Citations

Apr 16, 2003·Gynecologic Oncology·Nicole ConcinChristian Marth
Mar 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H IwamotoK Hoshi
Dec 7, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M J Palayekar, T J Herzog
Jan 13, 2010·BMC Cancer·Erin B DickersonJohn F McDonald
Jul 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan WangMulan Ren
Jan 10, 2014·Molecular Diagnosis & Therapy·Henry D ReyesKimberly K Leslie
Oct 5, 2010·Women's Health·T S KristedjaM Cristea
Apr 19, 2013·Journal of Cancer Research and Clinical Oncology·Linjuan XuZehua Wang
Jul 3, 2013·Expert Opinion on Investigational Drugs·Matteo MorottiSimone Ferrero
Mar 31, 2004·Seminars in Oncology·Mitchell E GrossDavid B Agus
Feb 14, 2008·Expert Opinion on Therapeutic Targets·J Reibenwein, M Krainer
Dec 2, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J S NielsenA Jakobsen
Jan 1, 2010·Cancers·Emma DeanJurjees Hasan
Sep 29, 2004·Cancer·Laurie ElitMichael Fung Kee Fung
Apr 28, 2011·Molecular Imaging·Lucia M A CraneGooitzen M van Dam
Feb 19, 2005·Current Treatment Options in Oncology·Ami P VaidyaMichael V Seiden
Mar 23, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Cheng-Han LeeC Blake Gilks
Jan 7, 2009·Current Opinion in Obstetrics & Gynecology·Fiona Collinson, Gordon Jayson
Jan 9, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Helen J Mackay, Amit M Oza
Dec 18, 2009·Expert Review of Anticancer Therapy·Claudia MarchettiSandro Pignata
Mar 16, 2012·Future Medicinal Chemistry·Jason A WilkenNita J Maihle
Jul 7, 2014·Journal of Cancer Research and Clinical Oncology·Xia LiuFuqiang Yin
Feb 18, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·José A García-SáenzEduardo Díaz-Rubio
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Lutfiye DemirMustafa Oktay Tarhan
Jun 17, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Rabab A A MohammedOmar M Shaaban

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.