PMID: 8582956Jul 1, 1995Paper

The growth hormone response to growth hormone-releasing hormone is blunted in polycystic ovary syndrome: relationship with obesity and hyperinsulinaemia

Human Reproduction
A LanzoneS Mancuso

Abstract

This study was designed to investigate the growth hormone (GH) secretory response to the growth hormone-releasing hormone (GHRH) test in women with polycystic ovary syndrome (PCOS). A total of 25 patients with PCOS (13 obese and 12 non-obese) and 15 normal ovulatory women (seven obese and eight non-obese) were included in this study. In the follicular phase patients were subjected to an oral glucose tolerance test (OGTT); 2 days later they underwent a GHRH test. Basal plasma concentrations of gonadotrophins, steroids and sex hormone-binding globulin were measured. Insulin and GH were assayed under the OGTT and GHRH test respectively. Based on the insulin response to OGTT in the PCOS group, nine patients were classified as normoinsulinaemic and 16 as hyperinsulinaemic; none of the patients of the control group had a hyperinsulinaemic response to OGTT. Obese patients showed a trend towards a lower GH response to GHRH. Moreover, hyperinsulinaemic patients showed a significantly (P < 0.05) lower area under the curve for secretion of GH (AUC-GH) as compared to normo-insulinaemic patients. All PCOS patients exhibited a markedly decreased response of GH to GHRH compared with the control population. Obese and hyperinsulinaemic PCOS pat...Continue Reading

Citations

Jun 10, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dorte Glintborg, Marianne Andersen
Jun 30, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jill A RadackJon D Oden
Jul 5, 2003·Journal of Endocrinological Investigation·P VillaA Lanzone
Feb 10, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dorte Glintborg, Marianne Andersen
Mar 10, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alessandro CiresiCarla Giordano
Sep 1, 2013·Expert Review of Endocrinology & Metabolism·Dorte GlintborgMarianne Andersen
Sep 14, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Toru TakeuchiYuji Taketani
Aug 4, 2005·The Journal of Clinical Endocrinology and Metabolism·Dorte GlintborgMarianne Andersen
Feb 11, 2021·International Journal of Molecular Sciences·Antonio ManciniAndrea Silvestrini
Apr 19, 1996·Molecular and Cellular Endocrinology·R ApaA Lanzone

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