The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men

Journal of Applied Physiology
Keith A StokesKate L Gilbert

Abstract

A single 30-s sprint is a potent physiological stimulus for growth hormone (GH) release. However, repeated bouts of sprinting attenuate the GH response, possibly due to negative feedback via elevated systemic free fatty acids (FFA). The aim of the study was to use nicotinic acid (NA) to suppress lipolysis to investigate whether serum FFA can modulate the GH response to exercise. Seven nonobese, healthy men performed two trials, consisting of two maximal 30-s cycle ergometer sprints separated by 4 h of recovery. In one trial (NA), participants ingested NA (1 g 60 min before, and 0.5 g 60 and 180 min after sprint 1); the other was a control (Con) trial. Serum FFA was not significantly different between trials before sprint 1 but was significantly lower in the NA trial immediately before sprint 2 [NA vs. Con: mean (SD); 0.08 (0.05) vs. 0.75 (0.34) mmol/l, P < 0.05]. Peak and integrated GH were significantly greater following sprint 2 compared with sprint 1 in the NA trial [peak GH: 23.3 (7.0) vs. 7.7 (11.9) microg/l, P < 0.05; integrated GH: 1,076 (350) vs. 316 (527) microg.l(-1).60 min(-1), P < 0.05] and compared with sprint 2 in the Con trial [peak GH: 23.3 (7.0) vs. 5.2 (2.3) microg/l, P < 0.05; integrated GH: 1,076 (350) vs. 2...Continue Reading

References

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Citations

Sep 14, 2012·European Journal of Applied Physiology·Keith A StokesDylan Thompson
Jul 3, 2013·Sports Medicine·Gwendolyn A ThomasJeff S Volek
Aug 19, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Caroline SunderlandKeith A Stokes
Apr 21, 2012·Journal of Applied Physiology·Stacy R OliverPietro R Galassetti
Apr 23, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Michihiro KonAaron P Russell
Mar 1, 2014·Medicine and Science in Sports and Exercise·Bradley C NindlJohn F Patton
Jun 11, 2011·Journal of Applied Physiology·Borja GuerraJose A L Calbet
Apr 28, 2021·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Nitzan DrorAlon Eliakim

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