PMID: 9185035Jun 1, 1997Paper

The Guinea Pig Blinking Test: a comparison with human responses

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
A Bar-Ilan

Abstract

The Guinea Pig Blinking Test (2) was presented as a model for the selection and development of comfortable ocular formulations. This study compares human nociceptive responses and the blinking response of the guinea pig to different concentrations of a topically applied ophthalmic drug, sulfacetamide. The number of human subjects noting pain upon instillation of various concentrations of sulfacetamide (3) was compared to the blinking responses of guinea pigs treated with 2.5%-17.5% sulfacetamide. The number of blinks was counted over a period of 5 minutes following (1) saline (0.9% NaCl), and (2) 30-60 minutes later a test solution. A Blinking Index (B.I.) = blinks drug/blinks saline was calculated for each animal. The dose/response curves of both humans and guinea pigs were almost identical, showing a threshold at 5% sulfacetamide, followed by a linear increase, reaching a maximum at 12.5%-15% sulfacetamide. A 2.5% solution that elicited pain in 10% of human subjects yielded a B.I. = 1.04 +/- 0.05, whereas a 12.5% solution that elicited pain in 95% of human subjects yielded a B.I. = 1.61 +/- 0.13 (mean +/- S.E., n = 10, P < 0.05). The strong linear relationship between the guinea pig blinking response and the human perception ...Continue Reading

References

Jan 1, 1990·Journal of Ocular Pharmacology·R VogelR W Tipping
Jan 1, 1986·Archives of Ophthalmology·R H StewartR L Ward
May 15, 1986·American Journal of Ophthalmology·R C AllenD L Epstein

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Citations

May 19, 2005·Journal of Cataract and Refractive Surgery·Renée SolomonHerb E Greenman
Dec 4, 2003·Ophthalmology·Bruce I Gaynes

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