The Gut Ecosystem: A Critical Player in Stroke.

Neuromolecular Medicine
Rosa Delgado Jiménez, Corinne Benakis

Abstract

The intestinal microbiome is emerging as a critical factor in health and disease. The microbes, although spatially restricted to the gut, are communicating and modulating the function of distant organs such as the brain. Stroke and other neurological disorders are associated with a disrupted microbiota. In turn, stroke-induced dysbiosis has a major impact on the disease outcome by modulating the immune response. In this review, we present current knowledge on the role of the gut microbiome in stroke, one of the most devastating brain disorders worldwide with very limited therapeutic options, and we discuss novel insights into the gut-immune-brain axis after an ischemic insult. Understanding the nature of the gut bacteria-brain crosstalk may lead to microbiome-based therapeutic approaches that can improve patient recovery.

References

Jul 6, 2006·Applied and Environmental Microbiology·Phyllis M O'DonnellGerald Sonnenfeld
Nov 7, 2009·Science·Elizabeth K CostelloRob Knight
May 22, 2010·Neurochemical Research·Raf BrounsPeter P De Deyn
Apr 22, 2011·Nature·Manimozhiyan ArumugamPeer Bork
Mar 7, 2012·Nature Reviews. Gastroenterology & Hepatology·John B Furness
May 15, 2015·Cell Host & Microbe·Timothy R Sampson, Sarkis K Mazmanian
Mar 29, 2016·Nature Medicine·Corinne BenakisJosef Anrather
Apr 9, 2016·Stroke; a Journal of Cerebral Circulation·Katarzyna WinekUlrich Dirnagl
Jul 15, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vikramjeet SinghArthur Liesz
Nov 1, 2016·Nature Medicine·Dragana StanleyConnie H Y Wong
Oct 7, 2016·Nature Medicine·Bjoern O Schroeder, Fredrik Bäckhed
Nov 5, 2016·Cell·Gil SharonSarkis K Mazmanian
Mar 30, 2017·Brain, Behavior, and Immunity·Rebecca SadlerArthur Liesz
Jan 14, 2018·Scientific Reports·Dragana StanleyConnie H Y Wong
Apr 8, 2018·Mucosal Immunology·Bruno LamasHarry Sokol
May 8, 2018·Annals of Neurology·Monica S SpychalaLouise D McCullough
May 31, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vikramjeet SinghArthur Liesz
Jan 17, 2019·Immunity·Geoffrey N Pronovost, Elaine Y Hsiao
Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Dec 10, 2019·Current Opinion in Neurobiology·Corinne BenakisPaul Wilmes
Jan 1, 2020·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca SadlerArthur Liesz
May 2, 2020·Circulation Research·Juneyoung LeeVenugopal Reddy Venna
May 15, 2020·Stroke; a Journal of Cerebral Circulation·Corinne BenakisJosef Anrather

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