The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation

Cell Reports
Shuisong CaoRongcun Yang

Abstract

Commensal microbes are necessary for a healthy gut immune system. However, the mechanism involving these microbes that establish and maintain gut immune responses is largely unknown. Here, we have found that the gut immune receptor leucine-rich repeat (LRR) C19 is involved in host-microbiota interactions. LRRC19 deficiency not only impairs the gut immune system but also reduces inflammatory responses in gut tissues. We demonstrate that the LRRC19-associated chemokines CCL6, CCL9, CXCL9, and CXCL10 play a critical role in immune cell recruitment and intestinal inflammation. The expression of these chemokines is associated with regenerating islet-derived (REG) protein-mediated microbiotas. We also found that the expression of REGs may be regulated by gut Lactobacillus through LRRC19-mediated activation of NF-κB. Therefore, our study establishes a regulatory axis of LRRC19, REGs, altered microbiotas, and chemokines for the recruitment of immune cells and the regulation of intestinal inflammation.

References

Apr 1, 1997·Immunological Reviews·A M Mowat, J L Viney
Aug 2, 2006·Immunity·Seth Rakoff-NahoumRuslan Medzhitov
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
Sep 24, 2009·Cancer Research·Boryana Konstantinova PopivanovaNaofumi Mukaida
Mar 6, 2010·Science·Matam Vijay-KumarAndrew T Gewirtz
Oct 12, 2010·Science·Shinichiro SawaGérard Eberl
Sep 3, 2011·Immunological Reviews·Matthew T Sorbara, Dana J Philpott
Oct 23, 2012·Cell Host & Microbe·Ivaylo I Ivanov, Kenya Honda
Jan 16, 2013·Immunology and Cell Biology·Yoshiyuki Goto, Ivaylo I Ivanov

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Citations

Apr 7, 2016·Cell Host & Microbe·Deepshika Ramanan, Ken Cadwell
Oct 31, 2019·Molecular Biology and Evolution·Melissah RoweSteve Dorus
Mar 25, 2019·Journal of Dairy Science·L H S IungG B Mourão
Sep 4, 2020·Communications Biology·Houbao QiRongcun Yang
Jul 18, 2017·Frontiers in Immunology·Floris FransenPaul de Vos
May 18, 2019·Communications Biology·Houbao QiRongcun Yang
Jan 12, 2020·Communications Biology·Houbao QiRongcun Yang

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Datasets Mentioned

BETA
BLAST

Methods Mentioned

BETA
ubiquitination
transgenic
flow cytometry
PCR

Software Mentioned

BLAST
MUSLE

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