The gut fungus Basidiobolus ranarum has a large genome and different copy numbers of putatively functionally redundant elongation factor genes.

PloS One
Daniel A Henk, Matthew C Fisher

Abstract

Fungal genomes range in size from 2.3 Mb for the microsporidian Encephalitozoon intestinalis up to 8000 Mb for Entomophaga aulicae, with a mean genome size of 37 Mb. Basidiobolus, a common inhabitant of vertebrate guts, is distantly related to all other fungi, and is unique in possessing both EF-1α and EFL genes. Using DNA sequencing and a quantitative PCR approach, we estimated a haploid genome size for Basidiobolus at 350 Mb. However, based on allelic variation, the nuclear genome is at least diploid, leading us to believe that the final genome size is at least 700 Mb. We also found that EFL was in three times the copy number of its putatively functionally overlapping paralog EF-1α. This suggests that gene or genome duplication may be an important feature of B. ranarum evolution, and also suggests that B. ranarum may have mechanisms in place that favor the preservation of functionally overlapping genes.

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Citations

Feb 26, 2014·BMC Evolutionary Biology·Gemma C AtkinsonVasili Hauryliuk
Sep 3, 2014·Genome Biology and Evolution·Kirill V MikhailovVladimir V Aleoshin
Oct 22, 2016·Molecular Phylogenetics and Evolution·Martin CarrFrank Nitsche
Apr 26, 2019·Biological Reviews of the Cambridge Philosophical Society·Miguel A Naranjo-Ortiz, Toni Gabaldón
Apr 18, 2020·Biological Reviews of the Cambridge Philosophical Society·Miguel A Naranjo-Ortiz, Toni Gabaldón
Oct 8, 2016·Molecular Ecology·Henrik H De Fine LichtJørgen Eilenberg
Aug 31, 2018·Clinical Microbiology Reviews·Raquel Vilela, Leonel Mendoza
Nov 8, 2020·Applied and Environmental Microbiology·Jacob M WurlitzerMarkus Gressler

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Datasets Mentioned

BETA
JN817948-JN817965

Methods Mentioned

BETA
PCR
fluorescence microscopy

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