The Gut Microbiome as a Component of the Gut-Brain Axis in Cognitive Health.

Biological Research for Nursing
Wen GaoSheila A Alexander

Abstract

The human microbiome, the microorganisms living in and on the body, plays a vital role in brain physiology and pathophysiology. The gut microbiome (GMB) has been identified as a link in the gut-brain axis moderating cognitive development and health. The objectives of this scoping review are to discuss mechanisms of the microbiome-gut-brain axis in cognition, review the existing literature on the GMB and cognition, and discuss implications for nursing research. We searched Pubmed using the terms "gut microbiome," "brain," and "cognition" and the terms "gut brain axis," "microbiome," and "cognition"; removed duplicates, studies not published in English, and unrelated publications; and added additional articles identified through references. We retained the 85 most relevant publications for this review. Common themes in the current literature include GMB components; interactions on cognitive development; effects of GMB-gut-brain interactions on cognition, mild cognitive impairment and Alzheimer's disease; effects of GMB interactions with physiologic stress on cognition in critical care; and GMB modification for improved cognition. Review of the literature on each of these topics reveals multiple theoretical mechanisms of action fo...Continue Reading

References

Apr 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Gustavo ProvensiMaria Beatrice Passani

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Citations

Jun 3, 2021·Animals : an Open Access Journal From MDPI·Sha JiangHeng-Wei Cheng
Jun 3, 2021·International Journal of Molecular Sciences·Thayza Martins MelzerPatricia S Brocardo

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