The Gut Microbiome in Polycystic Ovary Syndrome and Its Association with Metabolic Traits.

The Journal of Clinical Endocrinology and Metabolism
Kreete LüllElin Org

Abstract

Despite the gut microbiome being widely studied in metabolic diseases, its role in polycystic ovary syndrome (PCOS) has been scarcely investigated. Compare the gut microbiome in late fertile age women with and without PCOS and investigate whether changes in the gut microbiome correlate with PCOS-related metabolic parameters. Prospective, case-control study using the Northern Finland Birth Cohort 1966. General community. A total of 102 PCOS women and 201 age- and body mass index (BMI)-matched non-PCOS control women. Clinical and biochemical characteristics of the participants were assessed at ages 31 and 46 and analyzed in the context of gut microbiome data at the age of 46. (s): None. Bacterial diversity, relative abundance, and correlations with PCOS-related metabolic measures. Bacterial diversity indices did not differ significantly between PCOS and controls (Shannon diversity P = .979, unweighted UniFrac P = .175). Four genera whose balance helps to differentiate between PCOS and non-PCOS were identified. In the whole cohort, the abundance of 2 genera from Clostridiales, Ruminococcaceae UCG-002, and Clostridiales Family XIII AD3011 group, were correlated with several PCOS-related markers. Prediabetic PCOS women had significa...Continue Reading

References

Jan 1, 1988·Paediatric and Perinatal Epidemiology·P Rantakallio
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Mar 13, 2010·PloS One·Morgan N PriceAdam P Arkin
Apr 22, 2011·Nature·Manimozhiyan ArumugamPeer Bork
May 11, 2012·Gut Microbes·Harry J FlintEvelyne Forano
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
May 31, 2013·Nature·Fredrik H KarlssonFredrik Bäckhed
Jul 12, 2013·PloS One·Andrew D FernandesGregory B Gloor
Oct 12, 2014·Current Hypertension Reports·Manuel Luque-Ramírez, Héctor F Escobar-Morreale
Dec 3, 2014·Current Opinion in Biotechnology·Ruth Ann Luna, Jane A Foster
Oct 11, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gillian M BarlowRuchi Mathur
Nov 7, 2015·Science·Katharine Z CoyteKevin R Foster
Dec 15, 2015·The Journal of Clinical Endocrinology and Metabolism·Meri-Maija E OllilaL Morin-Papunen
May 24, 2016·Nature Methods·Benjamin J CallahanSusan P Holmes
Jun 10, 2016·Nature·Rachel J PerryGerald I Shulman
Jul 8, 2016·Nature·Justin L Sonnenburg, Fredrik Bäckhed
Jul 15, 2016·Nature·Helle Krogh PedersenOluf Pedersen
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Salla KarjulaTerhi T Piltonen
Sep 11, 2017·Brain, Behavior, and Immunity·Julieta SchachterJohn D Young
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Katrine Hass RubinMarianne Andersen
Jan 26, 2018·The Journal of Clinical Endocrinology and Metabolism·Pedro J TorresVarykina G Thackray
Jan 31, 2018·Diabetologia·Kristine H AllinOluf Pedersen
Feb 7, 2018·The Journal of Clinical Endocrinology and Metabolism·Filip OttossonMarju Orho-Melander
Jun 14, 2018·The Journal of Clinical Endocrinology and Metabolism·María InsenserHéctor F Escobar-Morreale
Jun 15, 2018·Gut·Judith Aron-WisnewskyKarine Clément
Jul 24, 2018·MSystems·J Rivera-PintoM L Calle
Aug 14, 2018·Fertility and Sterility·Inmaculada Moreno, Carlos Simon
Dec 7, 2018·Trends in Endocrinology and Metabolism : TEM·Varykina G Thackray
Feb 6, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E KoivuahoT T Piltonen
Feb 6, 2019·Nature Microbiology·Mireia Valles-ColomerJeroen Raes
Apr 17, 2019·Journal of Clinical Medicine·Negar NaderpoorBarbora de Courten

❮ Previous
Next ❯

Citations

Jun 1, 2021·Frontiers in Microbiology·Tao FengÁkos Kenéz
Nov 16, 2021·Frontiers in Cellular and Infection Microbiology·Wei GuanJian Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the Endocrine Society
Maryan G Rizk, Varykina G Thackray
The Journal of Clinical Endocrinology and Metabolism
Pedro TorresVarykina G Thackray
Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Lan WangLing Wang
The Journal of Clinical Endocrinology and Metabolism
Nesrin Damla EyupogluBulent Okan Yildiz
© 2021 Meta ULC. All rights reserved