The gut microbiome is associated with brain structure and function in schizophrenia.

Scientific Reports
Shijia LiKai Wu

Abstract

The effect of the gut microbiome on the central nervous system and its possible role in mental disorders have received increasing attention. However, knowledge about the relationship between the gut microbiome and brain structure and function is still very limited. Here, we used 16S rRNA sequencing with structural magnetic resonance imaging (sMRI) and resting-state functional (rs-fMRI) to investigate differences in fecal microbiota between 38 patients with schizophrenia (SZ) and 38 demographically matched normal controls (NCs) and explored whether such differences were associated with brain structure and function. At the genus level, we found that the relative abundance of Ruminococcus and Roseburia was significantly lower, whereas the abundance of Veillonella was significantly higher in SZ patients than in NCs. Additionally, the analysis of MRI data revealed that several brain regions showed significantly lower gray matter volume (GMV) and regional homogeneity (ReHo) but significantly higher amplitude of low-frequency fluctuation in SZ patients than in NCs. Moreover, the alpha diversity of the gut microbiota showed a strong linear relationship with the values of both GMV and ReHo. In SZ patients, the ReHo indexes in the right ...Continue Reading

References

Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
May 11, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·R K RaoP Sheth
Sep 1, 2007·NeuroImage·John Ashburner
Aug 13, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hironobu FujiwaraToshiya Murai
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Feb 12, 2011·Current Topics in Behavioral Neurosciences·James J LevittPadmapriya Srinivasan
Mar 17, 2011·Nature Reviews. Neuroscience·Ryota Kanai, Geraint Rees
Aug 1, 2012·PloS One·Mary A M RogersDavid M Aronoff
Jan 22, 2013·Journal of Hepatology·Genta KakiyamaJasmohan S Bajaj
Mar 7, 2013·Metabolic Brain Disease·Radha K Dhiman
May 22, 2013·Molecular Psychiatry·L DesbonnetJ F Cryan
Sep 23, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Katlyn NemaniXiaoduo Fan
Oct 1, 2014·The Proceedings of the Nutrition Society·Harry J FlintPetra Louis
Dec 3, 2014·Physiology & Behavior·Aleksandra TomovaDaniela Ostatnikova
Dec 3, 2014·Current Opinion in Microbiology·Mariagrazia Pizza, Rino Rappuoli
Jul 15, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lili Jiang, Xi-Nian Zuo
Jun 9, 2016·Nature Reviews. Gastroenterology & Hepatology·Christopher LeungPeter W Angus
Aug 5, 2016·Journal of Psychiatric Research·John R KellyTimothy G Dinan
Aug 20, 2016·The Journal of Neuropsychiatry and Clinical Neurosciences·M Soledad CepedaClair Blacketer
Dec 9, 2016·Environmental Microbiology·Petra Louis, Harry J Flint
Jul 1, 2017·Psychosomatic Medicine·Kirsten TillischJennifer S Labus
Feb 7, 2018·Journal of Psychiatric Research·Tanya T NguyenDilip V Jeste
Apr 10, 2018·Psychiatry Research. Neuroimaging·Wenbin GuoJingping Zhao
Jun 9, 2018·International Journal of Molecular Sciences·Valentina Caputi, Maria Cecilia Giron
Jun 29, 2018·Journal of Clinical Immunology·Isabelle Meyts, Ivona Aksentijevich
Sep 25, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yuchao JiangDezhong Yao

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