The gut microbiome primes a cerebroprotective immune response after stroke

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Vikramjeet SinghArthur Liesz

Abstract

Microbiome alterations have been shown to affect stroke outcome. However, to what extent the presence of a gut microbiome per se is affecting post-stroke neuroinflammation has not been tested. By comparing germfree mice with recolonized (Ex-GF) and conventional SPF mice, we were able to demonstrate that bacterial colonization reduces stroke volumes. Bacterial colonization increased cerebral expression of cytokines as well as microglia/macrophage cell counts in contrast to improved stroke outcome. Interestingly, the microbiome-mediated brain protection was absent in lymphocyte-deficient mice. These findings support the concept of lymphocyte-driven protective neuroinflammation after stroke under control of the microbiome.

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Citations

Jul 6, 2019·Stroke; a Journal of Cerebral Circulation·David J DurganRobert M Bryan
Jul 3, 2019·Nature Reviews. Neurology·Guido Stoll, Bernhard Nieswandt
Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
May 15, 2020·Stroke; a Journal of Cerebral Circulation·Corinne BenakisJosef Anrather
May 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ligen ShiYejie Shi
Oct 28, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carla CirilloIsabelle Loubinoux
Jul 17, 2020·Frontiers in Neurology·Denise BattagliniPatricia Rieken Macedo Rocco
Jul 12, 2019·Frontiers in Immunology·Joanne E KonkelSiddharth Krishnan
Aug 10, 2019·Frontiers in Neuroscience·Ximena CastilloMarietta Zille
Oct 1, 2019·Annual Review of Psychology·Joana S Cruz-PereiraJohn F Cryan
Feb 18, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Brooke BonsackCesar V Borlongan
Apr 14, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C SchneiderS Mundiyanapurath
Oct 13, 2020·Stroke; a Journal of Cerebral Circulation·William H RothHooman Kamel
Dec 22, 2020·Frontiers in Neuroscience·Julie JeonHea Jin Park
Jan 20, 2021·CNS Neuroscience & Therapeutics·Justin ChoCesar V Borlongan
Jan 14, 2021·PloS One·Yee Teng LeeLoo Keat Wei
Nov 19, 2020·Neuromolecular Medicine·Rosa Delgado Jiménez, Corinne Benakis
Feb 24, 2021·Brain, Behavior, and Immunity·Vikramjeet SinghMatthias Gunzer
Mar 12, 2021·Acta Neuropathologica Communications·Marta CelorrioStuart H Friess
Jun 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jia-Ting HuangLi-Shun Wang
Sep 19, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Qin Huang, Jian Xia
Sep 21, 2021·Biochemical Pharmacology·Drishti P GhelaniT Michael De Silva

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Methods Mentioned

BETA
PCR
flow cytometry

Software Mentioned

ARRIVE

Related Concepts

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Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

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