The Gut Microbiota: How Does It Influence the Development and Progression of Liver Diseases

Biomedicines
Paulraj KanmaniHojun Kim

Abstract

The gut-liver axis plays important roles in both the maintenance of a healthy liver and the pathogenesis of liver diseases, where the gut microbiota acts as a major determinant of this relationship. Gut bacteria-derived metabolites and cellular components are key molecules that affect the function of the liver and modulate the pathology of liver diseases. Accumulating evidence showed that gut microbiota produces a myriad of molecules, including lipopolysaccharide, lipoteichoic acid, peptidoglycan, and DNA, as well as short-chain fatty acids, bile acids, trimethylamine, and indole derivatives. The translocation of these components to the liver exerts beneficial or pathogenic effects by interacting with liver immune cells. This is a bidirectional relationship. Therefore, the existence of crosstalk between the gut and liver and its implications on host health and diseases are essential for the etiology and treatment of diseases. Several mechanisms have been proposed for the pathogenesis of liver diseases, but still, the mechanisms behind the pathogenic role of gut-derived components on liver pathogenesis remain elusive and not understandable. This review discusses the current progress on the gut microbiota and its components in te...Continue Reading

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Citations

Apr 4, 2021·Nutrients·Andreas Blesl, Vanessa Stadlbauer
Apr 1, 2021·Microbes and Infection·Meggie KuypersThierry Mallevaey
Jul 3, 2021·Diseases·Emanuel Vamanu, Sachchida Nand Rai

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