The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

Nature Communications
Alida KindtJosef Ecker

Abstract

Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic, phosphoproteomic, and lipidomic analyses of liver and plasma samples from germfree and specific pathogen-free mice. Microbes induce monounsaturated fatty acid generation by stearoyl-CoA desaturase 1 and polyunsaturated fatty acid elongation by fatty acid elongase 5, leading to significant alterations in glycerophospholipid acyl-chain profiles. A composite classification score calculated from the observed alterations in fatty acid profiles in germfree mice clearly differentiates antibiotic-treated mice from untreated controls with high sensitivity. Mechanistic investigations reveal that acetate originating from gut microbial degradation of dietary fiber serves as precursor for hepatic synthesis of C16 and C18 fatty acids and their related glycerophospholipid species that are also released into the circulation.

References

Feb 1, 1981·The Journal of Nutrition·J L SlavinJ A Marlett
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Makoto Miyazaki, James M Ntambi
Apr 12, 2003·Progress in Lipid Research·Stuart SmithAnil K Joshi
Oct 7, 2004·Journal of the American Society for Mass Spectrometry·Karin A Zemski Berry, Robert C Murphy
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Jan 18, 2005·Journal of Lipid Research·Yun WangDonald B Jump
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Oct 4, 2007·International Journal of Systematic and Evolutionary Microbiology·Jongsik ChunYoung-Woon Lim
Jan 17, 2008·Progress in Lipid Research·Gerd Schmitz, Josef Ecker
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Oct 8, 2008·Journal of Lipid Research·Young-Ah MoonJay D Horton
Jan 13, 2009·Biochimica Et Biophysica Acta·Yan QinHilde I Nebb
Dec 31, 2009·Journal of Lipid Research·Vidya R VelagapudiFredrik Bäckhed
Mar 17, 2010·Journal of Lipid Research·Max SchererGerhard Liebisch
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Josef EckerGerd Schmitz
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Oct 20, 2010·BMC Genomics·Daniel M GattiFred A Wright
Dec 15, 2010·Cell·Markus R Wenk
Jan 25, 2011·Journal of Proteome Research·Jürgen CoxMatthias Mann
Aug 6, 2011·Cell·Timothy R PetersonDavid M Sabatini
Aug 16, 2011·Gastroenterology·K B M Saiful IslamAtsushi Yokota
Aug 24, 2011·Annals of Nutrition & Metabolism·Fredrik Bäckhed
Sep 6, 2011·Applied and Environmental Microbiology·David BerryAlexander Loy
May 1, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Josef EckerGerhard Liebisch
May 11, 2012·Gut Microbes·Harry J FlintEvelyne Forano
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jennifer R DwyerKaren Reue
Sep 25, 2012·Progress in Lipid Research·Leanne Hodson, Barbara A Fielding
Nov 30, 2012·Nucleic Acids Research·Christian QuastFrank Oliver Glöckner
Mar 29, 2013·Science Translational Medicine·Alice P LiouLee M Kaplan
Apr 4, 2013·Journal of Lipid Research·Gerhard LiebischMichael J O Wakelam

❮ Previous
Next ❯

Citations

Dec 12, 2018·Natural Product Reports·Xue Ming Wu, Ren Xiang Tan
Sep 24, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·I Jane CoxJasmohan S Bajaj
Jan 30, 2020·Genome Research·Robert H MillsDavid J Gonzalez
Jan 30, 2020·Nutrients·Ignasi Azagra-BoronatMaria J Rodríguez-Lagunas
Mar 14, 2020·Journal of Applied Toxicology : JAT·Xiaohui LiLianhui Wang
Jan 30, 2020·Frontiers in Cellular and Infection Microbiology·Mayssa AlboueryMarie-Agnès Bringer
Nov 11, 2019·Reviews in Endocrine & Metabolic Disorders·Marc Schoeler, Robert Caesar
Feb 11, 2020·Frontiers in Cellular and Infection Microbiology·Mari Murakami, Paola Tognini
Feb 4, 2021·Comprehensive Reviews in Food Science and Food Safety·Yandan WangXingguo Wang
Dec 12, 2020·Metabolites·Holden C WilliamsLance A Johnson
Nov 17, 2020·Frontiers in Endocrinology·Kavita Jadhav, Taylor S Cohen
Jan 26, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Ruiqi Tang, Lanjuan Li
Nov 4, 2020·Journal of Clinical Medicine·Lara Costantini, Nicolò Merendino
Jan 21, 2021·Metabolites·Santosh LamichhaneMatej Orešič
Nov 14, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xuemei GuZhongbin Deng
Mar 5, 2021·International Journal of Medical Microbiology : IJMM·Gerhard LiebischJosef Ecker
Apr 1, 2021·Microbes and Infection·Giuliano BayerDana J Philpott
Apr 27, 2021·Frontiers in Physiology·María Daniella CarrettaRafael Agustín Burgos
May 22, 2021·Microbiome·Sofia M Murga-GarridoFederico E Rey
May 24, 2021·The Science of the Total Environment·Huiying GuoJinshao Ye
May 22, 2021·Experimental & Molecular Medicine·Grace ParkCholsoon Jang
Jun 3, 2021·Nutrients·Karolin WeitkunatSusanne Klaus

❮ Previous
Next ❯

Datasets Mentioned

BETA
E-MTAB-6079
PXD010412

Methods Mentioned

BETA
PCR
Feature Extraction
acetylation
PCA

Software Mentioned

UPARSE
glmnet
limma
Andromeda
Feature Extraction
R Core Team
R
cor
EzTaxon
MaxQuant

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.