The H19 locus acts in vivo as a tumor suppressor.

Proceedings of the National Academy of Sciences of the United States of America
Tomomi YoshimizuL Dandolo

Abstract

The H19 locus belongs to a cluster of imprinted genes that is linked to the human Beckwith-Wiedemann syndrome. The expression of H19 and its closely associated IGF2 gene is frequently deregulated in some human tumors, such as Wilms' tumors. In these cases, biallelic IGF2 expression and lack of expression of H19 are associated with hypermethylation of the imprinting center of this locus. These observations and others have suggested a potential tumor suppressor effect of the H19 locus. Some studies have also suggested that H19 is an oncogene, based on tissue culture systems. We show, using in vivo murine models of tumorigenesis, that the H19 locus controls the size of experimental teratocarcinomas, the number of polyps in the Apc murine model of colorectal cancer and the timing of appearance of SV40-induced hepatocarcinomas. The H19 locus thus clearly displays a tumor suppressor effect in mice.

References

May 9, 1991·Nature·M S BartolomeiS M Tilghman
Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Sep 1, 1995·Genes & Development·P A LeightonS M Tilghman
Oct 21, 1993·Nature·Y HaoB Tycko
Jul 1, 1994·Nature Genetics·T MoultonB Tycko
Oct 3, 1999·The Journal of Biological Chemistry·M A FrevelA E Reeve
Apr 2, 2003·Human Molecular Genetics·Rosanna WeksbergPaul Sadowski
Dec 19, 2003·Human Molecular Genetics·Maria VernucciAndrea Riccio
Oct 27, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sabine ColnotChristine Perret
Feb 26, 2005·Science·Takashi SakataniAndrew P Feinberg
May 12, 2005·American Journal of Medical Genetics. Part a·P RumpA J van Essen
Jul 7, 2005·European Journal of Human Genetics : EJHG·Wendy N CooperEamonn R Maher
Apr 1, 2006·Cytogenetic and Genome Research·A GaboryL Dandolo
Apr 4, 2006·Nucleic Acids Research·Junichi MinenoIkunoshin Kato
Jan 24, 2007·RNA·Xuezhong Cai, Bryan R Cullen
Sep 6, 2007·PloS One·Imad J MatoukEithan Galun

❮ Previous
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Citations

Nov 18, 2010·Familial Cancer·Erik F Hensen, Jean-Pierre Bayley
Jan 26, 2011·Expert Reviews in Molecular Medicine·Santiago Uribe-LewisAdele Murrell
Jun 10, 2011·European Journal of Human Genetics : EJHG·Samira Ibala-RomdhaneAnnick Lefèvre
Nov 30, 2010·Nucleic Acids Research·Paulo P AmaralJohn S Mattick
Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marilyn B RenfreeTomoko Kaneko-Ishino
Sep 18, 2009·Genes & Development·Marisa S Bartolomei
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Sep 26, 2013·Journal of Translational Medicine·Haojun SongJunming Guo
Jul 19, 2013·Annals of Surgical Oncology·J M HernandezD Shibata
Nov 3, 2009·The Journal of Reproduction and Development·Manabu KawaharaTomohiro Kono
Apr 25, 2009·PLoS Genetics·John S Mattick
Dec 4, 2009·PloS One·Jean-Pierre BayleyPeter E M Taschner
Apr 30, 2010·PloS One·Amit N Khachane, Paul M Harrison
Jul 28, 2013·International Journal of Molecular Sciences·Andoni Garitano-TrojaolaPuri Fortes
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Paul MonnierLuisa Dandolo
Apr 12, 2014·Journal of Molecular Cell Biology·Ali ZhangYin-Yuan Mo
Jun 8, 2012·EMBO Molecular Medicine·Victoria L HaleyA Bassim Hassan
Dec 29, 2010·Autoimmune Diseases·Kemal Ugur TufekciKursad Genc
May 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Long LiuXiaoqiang Yue
Aug 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bing YanLong Liu
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Shirley M Tilghman
Oct 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mohammadreza HajjariYoung Kee Shin
Sep 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoqiang GuoKaiyuan Deng
Mar 8, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mi-Die XuXiang Du
Jul 15, 2015·Critical Reviews in Biochemistry and Molecular Biology·Shabnam MassahGratien G Prefontaine
Jan 25, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shou-Hua WangZhi-Wei Quan
Mar 10, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mustafa Isin, Nejat Dalay
Sep 30, 2015·Journal of Cellular and Molecular Medicine·Qian WuFeng Chen
Apr 13, 2011·Cancer Letters·Valentina MirisolaAngelo Salami
Jan 25, 2011·Seminars in Cell & Developmental Biology·Michael B Clark, John S Mattick
May 26, 2015·Biochimica Et Biophysica Acta·Chandrasekhar Kanduri

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