The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis

Medical Gas Research
Bruno Schneider HerreraMarcelo N Muscará

Abstract

In experimental periodontitis, non-steroidal antiinflammatory drugs (NSAIDs) effectively inhibit the resultant alveolar bone loss. However, their deleterious gastric effects, observed in both animals and humans, dramatically limit their long-term use. It has been proven that the addition of a hydrogen sulfide (H2S)-releasing moiety to classical NSAID structures results in antiinflammatory compounds with improved gastric safeness. In this way, we decided to compare the effects of naproxen with its H2S-releasing derivative ATB-346 on ligature-induced periodontitis in rats. Male Holtzman rats had a cotton ligature placed subgingivally around the lower right first molar during 7 days. During this period, groups of animals were daily treated with Na2S (a spontaneous H2S donor) or equimolar oral doses of naproxen (10 mg/kg) or ATB-346 (16 mg/kg). The mandibles were finally collected for histological analysis, radiographical measurements of alveolar bone loss and micro-computed tomography (μCT) analysis. Interleukin (IL)-1β, IL-6 and IL-10 were quantified in gingiva samples, and the stomachs were also collected for scoring of tissue damage and measurement of myeloperoxidase (MPO, a marker of granulocyte infiltration). Ligature-induced...Continue Reading

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Citations

Jan 26, 2016·Antioxidants·Maria GreabuBogdan Calenic
Nov 9, 2016·Medical Gas Research·Brandon J Dixon, John H Zhang
Dec 23, 2016·Medicinal Research Reviews·Catarina Pereira-LeiteSalette Reis
Apr 9, 2017·Antioxidants & Redox Signaling·John L WallaceGilberto de Nucci
Dec 14, 2018·Canadian Journal of Physiology and Pharmacology·Branislav KuraJán Slezák
Mar 15, 2019·Canadian Journal of Physiology and Pharmacology·Ming YangBaorong He
Jun 25, 2019·British Journal of Pharmacology·Mariela CastelblancoNathalie Busso
Oct 28, 2019·International Journal of Molecular Sciences·Laura GambariFrancesco Grassi
Feb 22, 2017·Medical Gas Research·Lei Huang
Nov 22, 2016·Medical Gas Research·Zhou-Heng Ye, Xue-Jun Sun
Aug 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nahzli DilekCsaba Szabo
Jun 18, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuankun ZhaiNeetu Tyagi
Aug 10, 2021·Frontiers in Pharmacology·Yanming HaoChong Li
Jul 18, 2018·European Journal of Pharmacology·Paolo FagoneFerdinando Nicoletti
Sep 22, 2020·Current Pharmaceutical Design·Jan SlezakMiroslav Barancik

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Methods Mentioned

BETA
X-ray
ELISA

Software Mentioned

CTvol
CTan
ImageJ

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