The haemodilution enhanced onset of coagulation as measured by the thrombelastogram is transient

European Journal of Anaesthesiology
T G RuttmannJ G Brock-Utne

Abstract

Crystalloid haemodilution has been widely found to enhance coagulation onset, but the duration of this effect has never been documented. Twelve healthy, consenting volunteers had a rapid infusion of 14 mL kg-1 of normal (0.9%) saline. Blood samples were taken, prior to (control), and immediately after (30 min) the rapid saline infusion was completed (30 min). They were then repeated at regular intervals up to 120 min. Haematocrit/platelet counts were taken to determine the degree of dilution and thrombelastograms, with and without platelet antagonists (ReoPro, Abciximab), were measured in all samples. Antithrombin levels were selectively measured. The haematocrit and platelet count showed a rapid dilutional decrease at 30 min (mean of -12.2% and -14.4%, respectively), with values returning towards baseline within 15 min after finishing the infusion. There was a significantly faster onset of coagulation (decrease in r-time) in the post-infusion sample (30 min) compared to control (P<0.05), again returning towards normal as the dilution effect was reversed. Similar thrombelastograms findings were evident in the plasma factor only group (platelets inhibited by ReoPro). Antithrombin levels changed in keeping with the haemodilution ...Continue Reading

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Citations

Jul 5, 2011·The Veterinary Record·P Vilar SaavedraG Couto
Apr 22, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maureen McMichaelPamela A Wilkins
Apr 15, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Paraskevi MatsotaGeorgia Kostopanagiotou
Nov 25, 2020·International Journal of Laboratory Hematology·Andreas G TsantesArgirios E Tsantes
May 4, 2021·Frontiers in Veterinary Science·Corrin J BoydLisa Smart

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