The haemodynamic effects of iodinated water soluble radiographic contrast media: a review

European Journal of Radiology
Sameh K MorcosJ O Karlsson

Abstract

All classes of iodinated water-soluble radiographic contrast media (RCM) are vasoactive with the iso-osmolar dimers inducing the least changes in the vascular tone. The mechanisms responsible for RCM-induced changes in the vascular tone are not fully understood and could be multifactorial. A direct effect on the vascular smooth muscle cells causing alterations in the ion exchanges across the cell membrane is thought to be an important factor in RCM-induced vasodilatation. The release of the endogenous vasoactive mediators adenosine and endothelin may also play a crucial role in the haemodynamic effects of RCM particularly in the kidney. In addition, the effects of RCM on blood rheology can cause a reduction in the blood flow in the microcirculation. The purpose of this review is to discuss the pathophysiology of the haemodynamic effects of RCM and to offer some insight into the biology of the endothelium and vascular smooth muscle cells as well as the pharmacology of the important vasoactive mediators endothelin and adenosine.

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Citations

Jun 22, 2005·European Radiology·Sameh K MorcosUNKNOWN Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
Jan 6, 2006·European Radiology·Peter AspelinUNKNOWN Members of the Contrast Media Safety Committee of the European Society of Urogenital Radiology (ESUR)
Jun 9, 2007·Pharmacy World & Science : PWS·Frank Ga JansmanJohannes W Harting
Jan 24, 2012·European Heart Journal·Erdmann SeeligerPontus B Persson
Apr 8, 2014·BioMed Research International·Erdmann SeeligerPontus B Persson
Oct 23, 2012·Vascular Pharmacology·Egeria ScodittiMaria Rosa Montinari
Dec 4, 2015·Nuklearmedizin. Nuclear Medicine·Soo J KimByung-Tae Kim
May 24, 2003·The British Journal of Radiology·S K Morcos
Feb 6, 1999·European Journal of Radiology·S K MorcosJ O Karlsson
May 23, 2017·Journal of Stomatology, Oral and Maxillofacial Surgery·R GryseleynJ Ferri
Apr 15, 2004·Clinical Radiology·S K Morcos
Mar 5, 2019·Clinical Nuclear Medicine·Thomas S C NgHeather A Jacene
Mar 9, 2006·Journal of the American College of Nutrition·Stephen A Hoption Cann
Aug 13, 2020·Thyroid : Official Journal of the American Thyroid Association·Cristina Maldonado-AraqueGemma Rojo-Martínez
Dec 24, 2002·Investigative Radiology·Werner Krause, Matthias Schromm

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