The haemodynamics of endovascular aneurysm treatment: a computational modelling approach for estimating the influence of multiple coil deployment

IEEE Transactions on Medical Imaging
N M P KakalisYiannis Ventikos


This paper proposes a novel computational methodology for modelling the haemodynamic effects of endovascular coil embolization for cerebral aneurysms. We employ high-resolution 3-D angiographic data to reconstruct the intracranial geometry and we model the coiled part of the aneurysm as a porous medium, with porosity decreasing as coils are inserted. The actual dimensions of the coils employed are used to determine the characteristics of the porous medium. Simulation results for saccular aneurysms from the anterior communicating and middle cerebral arteries show that insertion of coils rapidly changes intraaneurysmal blood flow and causes reduction in mural pressure and blood velocity up to stagnation, providing favorable conditions for thrombus formation and obliteration of the aneurysm.


Jan 1, 1989·Acta neurochirurgica·K F LindegaardP Nakstad
Nov 1, 1996·Stroke; a Journal of Cerebral Circulation·H UjiieK Takakura
Dec 12, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C GrodenH Zeumer
Jan 19, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·J R Boyle, G E Morris
Jun 21, 2002·Neurological Research·Baruch B Lieber, Matthew J Gounis
May 31, 2003·Stroke; a Journal of Cerebral Circulation·Jean RaymondDaniel Roy
Jul 18, 2003·Lancet·David O WiebersInternational Study of Unruptured Intracranial Aneurysms Investigators
Apr 15, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·N PouratianA S Dumont


Nov 3, 2010·Annals of Biomedical Engineering·L AugsburgerN Stergiopulos
Jan 19, 2013·Annals of Biomedical Engineering·Jason M OrtegaDuncan J Maitland
Apr 9, 2013·Medical & Biological Engineering & Computing·Woowon JeongKyehan Rhee
Jul 31, 2013·Journal of Biomechanics·Hernán G MoralesAlejandro F Frangi
May 19, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Maria-Cruz Villa-UriolAlejandro F Frangi
Aug 24, 2012·Journal of Neurointerventional Surgery·Hernán G MoralesAlejandro F Frangi
Oct 15, 2013·Biomedical Engineering Online·Andrea D MuschenbornDuncan J Maitland
Nov 23, 2013·Journal of Biomechanics·A J GeersAlejandro F Frangi
Mar 29, 2012·Computational and Mathematical Methods in Medicine·Woowon Jeong, Kyehan Rhee
Jan 1, 2009·The British Journal of Radiology·Yiannis VentikosJames V Byrne
Sep 3, 2011·AJNR. American Journal of Neuroradiology·Hernán G MoralesAlejandro F Frangi
Feb 18, 2016·Journal of Korean Neurosurgical Society·Kyung Min LeeSeung-Chyul Hong
Jul 4, 2012·Computer Methods and Programs in Biomedicine·Ignacio LarrabideAlejandro F Frangi
Apr 27, 2012·Journal of Magnetic Resonance Imaging : JMRI·Nils Daniel ForkertDennis Säring
Sep 26, 2012·IEEE Transactions on Medical Imaging·Hernán G MoralesAlejandro F Frangi
Nov 30, 2012·IEEE Transactions on Bio-medical Engineering·M Haithem BabikerDavid Frakes
Jul 23, 2016·Medical & Biological Engineering & Computing·Tomohiro OtaniShigeo Wada
May 11, 2017·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ali Sarrami-ForoushaniAlejandro F Frangi
Sep 15, 2016·Stroke; a Journal of Cerebral Circulation·Shin-Ichiro SugiyamaTeiji Tominaga
May 21, 2013·Cardiovascular Engineering and Technology·Chander SadasivanBaruch B Lieber
Oct 21, 2018·Cardiovascular Engineering and Technology·Hooman Yadollahi-FarsaniBrian Chong
May 16, 2019·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Junfan ChenXinjian Yang
Apr 20, 2018·Frontiers in Physiology·Malebogo N NgoepeYiannis Ventikos

Related Concepts

Blood Flow Velocity
Diastolic Blood Pressure
Mycotic Aneurysm, Intracranial
Cerebral Angiography
Structure of Cerebral Artery
In Silico
Embolization, Therapeutic
Medical Device Design
Therapy, Computer-Assisted

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