The haemostatic profile in critically ill COVID-19 patients receiving therapeutic anticoagulant therapy: An observational study

Medicine
Argirios E TsantesApostolos Armaganidis

Abstract

Hypercoagulability and thrombosis remain a challenge in severe coronavirus disease 2019 (COVID-19) infections. Our aim is to investigate the hemostatic profile of critically ill COVID-19 patients on therapeutic anticoagulant treatment.Forty one patients were enrolled into the study. We recruited 11 consecutive, COVID-19, patients who received therapeutic anticoagulant treatment on intensive care unit (ICU) admission. Disease severity indexes, biochemical, hematological and haemostatic parameters, endogenous thrombin potential (ETP), plasminogen activator inhibitor-1 (PAI-1) activity and extrinsically activated rotational thromboelastometry assay (EXTEM) were recorded on days 1, 3, 7. We also enrolled 9 ICU non-COVID-19, 21 non-ICU COVID-19 patients and 20 healthy blood donors as control populations.Critically ill COVID-19 patients demonstrated a more hypercoagulable and hypofibrinolytic profile related to those with COVID-19 mild illness, based on EXTEM amplitude at 10 min (A10), maximum clot firmness (MCF) and lysis index at 60 min (LI60) variables (p = 0.020, 0.046 and 0.001, respectively). Similarly, a more hypercoagulable state was detected in COVID-19 ICU patients related to non-COVID-19 ICU patients based on A10 and MCF p...Continue Reading

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Citations

Mar 27, 2021·Journal of the American College of Surgeons·Jonathan P MeizosoErnest E Moore
Jan 14, 2021·Korean journal of anesthesiology·Klaus GörlingerKhaled Ahmed Yassen
Apr 4, 2021·International Journal of Molecular Sciences·Machteld Sillen, Paul J Declerck
May 1, 2021·Journal of Clinical Medicine·Marion BareilleFrançois Mullier
May 26, 2021·European Geriatric Medicine·Mariana AlvesUNKNOWN EuGMS Special Interest Group inCardiovascular Medicine (Chairpersons A. Ungar and A. Benetos)
Jul 16, 2021·Journal of Clinical Monitoring and Computing·Vittorio PavoniDomenico Prisco

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