PMID: 6537952Feb 1, 1984Paper

The hagfish slime gland thread cell. I. A unique cellular system for the study of intermediate filaments and intermediate filament-microtubule interactions

The Journal of Cell Biology
S W DowningW L Salo

Abstract

Thread cell differentiation in the slime gland of the Pacific hagfish Eptatretus stouti has been studied using light microscopy and scanning and transmission electron microscopy. Thread cell differentiation is remarkable in that the life history of the cell is largely dedicated to the production of a single, tapered, cylindrical, highly coiled, and precisely packaged cytoplasmic thread that may attain lengths of 60 cm and diameters approaching 1.5 micron. Each tapered thread, in turn, is comprised almost entirely of large numbers of intermediate filaments (IFs) bundled in parallel. During differentiation of the thread, the IFs become progressively more tightly packed. Various numbers of microtubules (MTs) are found among the bundled IFs during differentiation of the thread but disappear during the latter stages of thread differentiation. Observations of regularly spaced dots in longitudinal bisections of developing threads, diagonal striations in tangential sections of developing threads, and circumferentially oriented, filament-like structures observed at the periphery of developing threads cut in cross section have led us to postulate a helically oriented component(s) wrapped around the periphery of the developing thread. The...Continue Reading

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Citations

Oct 1, 1995·International Journal of Biological Macromolecules·E A KochD A Parry
Jan 1, 1988·Preparative Biochemistry·D M GadboisD M Carlson
Jul 1, 2009·Integrative and Comparative Biology·Douglas S FudgeG H McKinley
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Mar 18, 2021·Soft Matter·Patrick A RühsPeter Fischer
May 11, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Noah Bressman, Douglas Fudge

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