The hair follicle and its stem cells as drug delivery targets

Expert Opinion on Drug Delivery
R M Hoffman

Abstract

The hair follicle is a skin appendage with a complex structure containing many cell types that produce highly specialised proteins. The hair follicle is in a continuous cycle: anagen is the hair growth phase, catagen the involution phase and telogen is the resting phase. The follicle offers many potential therapeutic targets. Hoffman and colleagues have pioneered hair-follicle-specific targeting using liposomes to deliver small and large molecules, including genes. They have also pioneered ex vivo hair-follicle targeting with continued expression of the introduced gene following transplantation. Recently, it has been discovered that hair follicle stem cells are highly pluripotent and can form neurons, glial cells and other cell types, and this has suggested that hair follicle stem cells may serve as gene therapy targets for regenerative medicine.

References

Sep 15, 1978·FEBS Letters·R M HoffmanL D Bergelson
Nov 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·L LiR M Hoffman
Nov 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·L LiR M Hoffman
Jul 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·L LiR M Hoffman
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L LiR M Hoffman
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L N LiR M Hoffman
May 1, 1991·Journal of Pharmaceutical Sciences·B IllelO Doucet
Jan 1, 1990·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·K EgbariaN Weiner
Apr 1, 1987·The British Journal of Dermatology·T LloydJ G Marks
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A E Freeman, R M Hoffman
Sep 1, 1971·Archives of Environmental Health·H I MaibachW F Serat
Feb 1, 1967·The Journal of Investigative Dermatology·R J Feldmann, H I Maibach
Oct 1, 1994·The Journal of Investigative Dermatology·D YaroshM Kripke
Mar 1, 1993·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·L LiR M Hoffman
Nov 26, 1999·Nature·A J ReynoldsC A Jahoda
Jan 14, 2000·Nature Biotechnology·R M Hoffman
Sep 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Norimitsu SaitoRobert M Hoffman
Aug 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lingna LiRobert M Hoffman
Aug 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yasuyuki AmohRobert M Hoffman
Apr 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yasuyuki AmohRobert M Hoffman
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yasuyuki AmohRobert M Hoffman

❮ Previous
Next ❯

Citations

Mar 19, 2008·Cell Stress & Chaperones·Joaquin J JimenezRichard Voellmy
Jan 6, 2009·PloS One·Mubashir HanifMaria Eriksson
Mar 1, 2011·Expert Opinion on Drug Discovery·Ajay SemaltyMohan Singh Maniyari Rawat
Apr 25, 2007·Annals of Medicine·Thomas G Jensen
Apr 5, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wing Cheung MakJürgen Lademann
Feb 17, 2009·Nature Chemical Biology·Sergi FerréRafael Franco
Feb 6, 2020·Cell and Tissue Banking·Saeideh AranArash Abdolmaleki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Dermatologic Clinics
C Jaworsky, A C Gilliam
Skin Pharmacology and Physiology
S MangelsdorfJ Lademann
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Juergen LademannWolfram Sterry
Skin Pharmacology and Physiology
J LademannWolfram Sterry
© 2022 Meta ULC. All rights reserved