The hallmarks of cell-cell fusion

Development
Javier M Hernández, Benjamin Podbilewicz

Abstract

Cell-cell fusion is essential for fertilization and organ development. Dedicated proteins known as fusogens are responsible for mediating membrane fusion. However, until recently, these proteins either remained unidentified or were poorly understood at the mechanistic level. Here, we review how fusogens surmount multiple energy barriers to mediate cell-cell fusion. We describe how early preparatory steps bring membranes to a distance of ∼10 nm, while fusogens act in the final approach between membranes. The mechanical force exerted by cell fusogens and the accompanying lipidic rearrangements constitute the hallmarks of cell-cell fusion. Finally, we discuss the relationship between viral and eukaryotic fusogens, highlight a classification scheme regrouping a superfamily of fusogens called Fusexins, and propose new questions and avenues of enquiry.

References

May 29, 2018·Journal of Evolutionary Biology·Anaïs TilquinHanna Kokko
Jul 20, 2018·PLoS Genetics·Stephan A RaidersJames R Priess
Aug 21, 2018·PLoS Biology·Theodore Clark
Jul 25, 2019·Journal of the Royal Society, Interface·Jing CongTianzhi Luo
Jun 4, 2019·Journal of Cell Science·Sophie G Martin
Nov 30, 2018·Nature Communications·Ilaria CastiglioniDavide Gabellini
Dec 18, 2019·The Prostate·Ruoxiang WangLeland W K Chung
Oct 24, 2019·Cellular and Molecular Life Sciences : CMLS·Bide ChenTizhong Shan
Mar 30, 2020·Journal of Cell Science·Yen-Ling LianLinyi Chen
Sep 19, 2019·Journal of Cell Science·Ji Hoon Kim, Elizabeth H Chen
May 3, 2018·Nature Communications·Fabien SoulavieMeera V Sundaram
Mar 10, 2019·Nature Plants·Philipp CyprysStefanie Sprunck
Feb 10, 2019·Cells·Julian Weiler, Thomas Dittmar
May 10, 2019·APL Bioengineering·Casey A ChitwoodBrenda M Ogle
Apr 3, 2019·The Journal of Cell Biology·Nicolas G BrukmanLeonid V Chernomordik
Feb 11, 2020·Frontiers in Microbiology·A Pedro GonçalvesN Louise Glass
Mar 12, 2020·International Journal of Molecular Sciences·Jessica DörnenThomas Dittmar
Jun 13, 2018·Frontiers in Neurology·Laurène M AndréBé Wieringa
Aug 4, 2019·Development·Hanisha H BhaktaMatteo A Avella
Aug 6, 2019·BioMed Research International·Erhui JiangZhengjun Shang
Jun 19, 2019·Cells·Jeffrey L Platt, Marilia Cascalho
Jun 17, 2019·Cellular and Molecular Life Sciences : CMLS·Gareth Bloomfield
Jul 10, 2019·Annual Review of Genetics·Donghoon M Lee, Elizabeth H Chen
Nov 28, 2019·Journal of Developmental Biology·Jonathan Hodgkin
Sep 16, 2020·International Journal of Molecular Sciences·Jiro Takito, Masanori Nakamura
Oct 27, 2020·Cytoskeleton·Claire M VenardTim Stearns

Citations

Feb 19, 1976·Nature·D M LeNeveuV A Parsegian
Apr 20, 1990·Journal of Molecular Biology·W I WeisD C Wiley
Jan 1, 1989·Annual Review of Biophysics and Biophysical Chemistry·T StegmannA Helenius
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Trueheart, G R Fink
Jan 1, 1989·European Biophysics Journal : EBJ·Michael M KozlovY A Chizmadzhev
Dec 21, 1987·Journal of Theoretical Biology·S L LeikinY A Chizmadzhev
Feb 1, 1994·Developmental Biology·Benjamin Podbilewicz, John G White
Aug 1, 1996·The Journal of Cell Biology·M KielianW A Duffus
Apr 7, 1998·Cell·T WeberJ E Rothman
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·J ChenD C Wiley
Jul 11, 2000·Molecular Biology of the Cell·E Leikina, Leonid V Chernomordik
Mar 7, 2002·Developmental Cell·William A MohlerBenjamin Podbilewicz
Apr 16, 2002·Molecular Biology of the Cell·Junmin Pan, William J Snell
Oct 25, 2002·The Journal of Biological Chemistry·Chenchou YuHungwen Chen
Dec 28, 2002·Genes & Development·Gidi Shemer, Benjamin Podbilewicz
Oct 7, 2003·Annual Review of Biochemistry·Leonid V Chernomordik, Michael M Kozlov
Oct 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sandra BlaiseThierry Heidmann
Sep 3, 2004·Current Biology : CB·Gidi ShemerBenjamin Podbilewicz

Related Concepts

Syncytium Formation by Plasma Membrane Fusion
Fertility
Myoblasts
Exertion
Tissue Membrane
Virus
Membrane
Caenorhabditis elegans
Env Glycoproteins
Target Membrane SNARE Proteins

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Cellular and Molecular Life Sciences : CMLS
D LangoschC Ungermann
Current Biology : CB
Nadav SegevBenjamin Podbilewicz
Indian Medical Gazette
Chetan Shah
© 2020 Meta ULC. All rights reserved