PMID: 8599058Jul 1, 1995Paper

The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections

Revista Do Instituto De Medicina Tropical De São Paulo
M S de Arruda, M R Montenegro

Abstract

The hamster cheek pouch is an invagination of oral mucosa, characterized histologically as skin-like. In this paper we describe anatomical, histological and embriological features of the pouch and comment on the pouch as an immunologically privileged site since it lacks lymphatic drainage and has few Langerhans cells. We present the review from literature and our observations after inoculation in the pouch of mycobacteriae (BCG, Mycobacterium tuberculosis and Mycobacterium leprae) and a fungus (Paracoccidioides brasiliensis). Lesions in the pouch were granulomatous but smaller and long lasting; even granulomatous, the reaction was inefficient to control the proliferation of agents compared with inoculation in other sites, except for BCG. Appearance of immunity was also delayed or absent and, when it was detected, a sharp decrease in number of agents in pouch lesions was observed. These observations make the pouch an interesting site for the study of the role of immune system in infectious diseases and in granuloma formation.

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Citations

Aug 10, 2002·Revista Da Sociedade Brasileira De Medicina Tropical·Maria Sueli Parreira de ArrudaAna Paula Bordon
Jul 22, 2005·Acta Cirúrgica Brasileira·Bernardo HochmanLydia Masako Ferreiras
Mar 14, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·M S de ArrudaF R Vilani-Moreno
Apr 8, 2014·Toxicologic Pathology·Holly L JordanShashi K Ramaiah
Nov 28, 2007·Veterinary Pathology·Julia H Riley

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