The hamster isolated trachea: a new preparation for studying NK-2 receptors.

European Journal of Pharmacology
C A MaggiA Meli

Abstract

Mammalian tachykinins (substance P, neurokinin A and neurokinin B) produced a concentration-related contraction of the hamster isolated trachea with the following order of potency: NKA congruent to NKB much greater than substance P (SP). NKA and NKB were 280 and 203 times more potent than SP, respectively. The action of NKA, NKB or SP was not significantly modified in presence of thiorphan (10 microM), atropine (1 microM), mepyramine (1 microM) or indomethacin (5 microM). [Nle10]NKA-(4-10) or [beta Ala8]NKA-(4-10), two selective NK-2 receptor agonists, displayed good activity while other synthetic agonists, selective for NK-1 or NK-3 receptors, had little or no effect. The contractile response to tachykinins did not undergo appreciable desensitization and was promptly reversed by washing out. These data indicate that NK-2 receptors are the main if not the sole mediators of the response of the hamster isolated trachea to tachykinins, whose action is independent from cholinergic nerves, histamine release or prostaglandin production. Further, no significant peptide degradation by a thiorphan-sensitive mechanism occurs in this organ.

References

Jan 1, 1985·Peptides·J E Maggio
Nov 4, 1986·European Journal of Pharmacology·C M LeeL L Iversen
Jan 12, 1987·Life Sciences·D RegoliP D'Orléans-Juste
Jul 1, 1987·Neuropeptides·G DrapeauD Regoli
May 1, 1989·Neuropeptides·P RoveroD Regoli
Jul 9, 1987·European Journal of Pharmacology·C AdvenierD Regoli
Mar 1, 1987·Journal of Autonomic Pharmacology·C A MaggiA Meli

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Citations

Jan 21, 1992·European Journal of Pharmacology·E J KusnerR D Krell
Dec 12, 1994·European Journal of Pharmacology·G F JoosR A Pauwels
Feb 1, 1993·Pharmacology & Therapeutics·Y D Pendry
May 4, 1995·Regulatory Peptides·U Holzer-Petsche
Apr 4, 1994·European Journal of Pharmacology·P ChitanoC E Mapp
May 23, 1998·European Journal of Pharmacology·A M ReynoldsR Scicchitano
Feb 1, 1993·Journal of Autonomic Pharmacology·C A MaggiA Giachetti
Jul 1, 1990·British Journal of Pharmacology·C A MaggiA Meli
Sep 1, 1991·British Journal of Pharmacology·R PatacchiniC A Maggi
Apr 1, 1992·British Journal of Pharmacology·S Manzini
Jan 1, 1991·Annals of the New York Academy of Sciences·C K BucknerJ M Vann
Mar 1, 2010·Current Protocols in Pharmacology·Stefania Meini, Carlo Alberto Maggi
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·J L Ellis
May 1, 1990·British Journal of Pharmacology·M ZicheC A Maggi
Aug 1, 1994·International Journal of Peptide and Protein Research·G HölzemannH E Greiner
Apr 1, 1993·International Journal of Peptide and Protein Research·U WollbornD Leibfritz

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