PMID: 6651364Dec 1, 1983Paper

The hand radiograph as a diagnostic discriminant between seropositive and seronegative 'rheumatoid arthritis': a controlled study

Annals of the Rheumatic Diseases
T M Burns, A Calin

Abstract

Although traditional teaching emphasises that 70-80% of patients with rheumatoid arthritis have positive serological tests for rheumatoid factor, a review of the evidence suggests that the seronegative group has distinctive characteristics. In a blinded and controlled evaluation of hand and wrist films we correctly identified the serological status of 43 out of 46 patients satisfying the ARA criteria for 'definite RA'. The radiographic appearances of the seronegative group differed significantly from those of the seropositive group in (1) degree of juxtalesional osteosclerosis (p less than 0.001); (2) the relative absence of classical subchondral erosions (p less than 0.001); (3) presence of new bone formation (p less than 0.001); (4) more fusion (p less than 0.001); (5) more asymmetrical joint involvement (p less than 0.001); and (6) predominant carpal involvement (p less than 0.001). The nature of the destructive process, as defined radiologically, may be different in patients with seropositive rheumatoid arthritis from that seen in individuals with so-called 'seronegative rheumatoid arthritis'.

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Citations

Jan 1, 1991·Rheumatology International·A MundingerG Sigmund
Jan 1, 1983·Rheumatology International·J Edelman, A S Russell
Sep 1, 1988·Clinical Rheumatology·T D Spector, D L Scott
Dec 15, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Samjin ChoiHun-Kuk Park
Feb 1, 1985·Annals of the Rheumatic Diseases·S K Lutalo
Apr 1, 1986·Annals of the Rheumatic Diseases·J T HallaJ G Hardin
May 1, 1986·Annals of the Rheumatic Diseases·D L ScottA J Popert
Aug 1, 1986·Annals of the Rheumatic Diseases·D JaraquemadaR N Maini
Aug 1, 1986·Annals of the Rheumatic Diseases·D J WalkerR J Powell
Feb 1, 1987·Annals of the Rheumatic Diseases·A J SilmanH L Currey
Sep 16, 2011·Computers in Biology and Medicine·Samjin ChoiHun-Kuk Park
Oct 23, 2012·International Journal of Rheumatic Diseases·Naomi IchikawaHisashi Yamanaka
Apr 27, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Philippe ZanggerEarl R Bogoch
Feb 1, 1992·Baillière's Clinical Rheumatology·D L Scott, E C Huskisson
Dec 1, 1987·Baillière's Clinical Rheumatology·J R Kirwan, A J Silman
Apr 21, 1999·Lancet·A Calin
Dec 3, 2014·Seminars in Arthritis and Rheumatism·Jenny Amaya-AmayaJuan-Manuel Anaya
Jul 17, 2013·Revista brasileira de reumatologia·Licia Maria Henrique da MotaUNKNOWN Colégio Brasileiro de Radiologia
Oct 2, 2001·Scandinavian Journal of Rheumatology·A J FeuerhermA Faxvaag
Oct 1, 1990·Arthritis and Rheumatism
May 28, 2019·Clinical Rheumatology·Gadeholt OttarPfeil Alexander
Jan 1, 1986·Arthritis and Rheumatism·J JacobM H Weisman

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