The Hap Complex in Yeasts: Structure, Assembly Mode, and Gene Regulation

Frontiers in Microbiology
Yinhe Mao, Changbin Chen

Abstract

The CCAAT box-harboring proteins represent a family of heterotrimeric transcription factors which is highly conserved in eukaryotes. In fungi, one of the particularly important homologs of this family is the Hap complex that separates the DNA-binding domain from the activation domain and imposes essential impacts on regulation of a wide range of cellular functions. So far, a comprehensive summary of this complex has been described in filamentous fungi but not in the yeast. In this review, we summarize a number of studies related to the structure and assembly mode of the Hap complex in a list of representative yeasts. Furthermore, we emphasize recent advances in understanding the regulatory functions of this complex, with a special focus on its role in regulating respiration, production of reactive oxygen species (ROS) and iron homeostasis.

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Citations

Oct 3, 2020·Applied Microbiology and Biotechnology·Andreas SchüllerJoseph Strauss
May 3, 2021·The Journal of Biological Chemistry·Manjit Kumar SrivastavKrishnamurthy Natarajan
Jul 7, 2021·Cellular and Molecular Life Sciences : CMLS·Eva-Maria EcklLucas T Jae

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Methods Mentioned

BETA
two-hybrid

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