The hare and the tortoise: one small step for four SNPs, one giant leap for SNP-kind.

Forensic Science International. Genetics
Yali Xue, C Tyler-Smith

Abstract

A recently published study has used next-gen sequencing technology to resequence two Y chromosomes separated by 13 generations and discovered four single-base differences in approximately 10Mb DNA, suggesting that the Y chromosome euchromatin accumulates around one mutation per generation. Y-SNPs therefore now offer the best resolution of Y haplotypes and promise to distinguish almost every Y chromosome. This work illustrates the promise of current sequencing technology for forensically relevant applications.

References

Jun 16, 2004·American Journal of Human Genetics·Manfred KayserChris Tyler-Smith
Oct 29, 2004·Nature Reviews. Genetics·Mark A Jobling, Peter Gill
Feb 12, 2008·Trends in Genetics : TIG·Elaine R Mardis
Jun 1, 2007·Forensic Science International. Genetics·Sascha WilluweitUNKNOWN International Forensic Y Chromosome User Group

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Citations

Nov 26, 2011·Investigative Genetics·Eva C BerglundAnn-Christine Syvänen
May 11, 2010·Forensic Science International. Genetics·António Amorim
Jan 29, 2013·Human Mutation·Vincent CastellaDiana Hall
Jun 29, 2015·Forensic Science International. Genetics·John M Butler
May 27, 2011·Forensic Science International. Genetics·Kaye N BallantyneManfred Kayser
Jun 23, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M J Alvarez-CuberoJ A Lorente

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