The harvest and use of autologous back-up grafts for graft failure or severe GVHD after allogeneic hematopoietic stem cell transplantation: a survey of the European Group for Blood and Marrow Transplantation

Bone Marrow Transplantation
M Stelljescomplications subcommittee of the Chronic Leukemia Working Party

Abstract

Autologous hematopoietic stem cells (HSCs) harvested as back-up prior to allogeneic hematopoietic SCT (HSCT) may potentially be useful in the treatment of graft failure or in cases with severe GVHD. Here, we studied the general policies and indications for autologous back-up harvest among the European Group for Blood and Marrow Transplantation centers in the year 2003. The outcome of patients receiving autologous back-up transfusion between 1998 and 2002 was evaluated retrospectively. The responses from 94 centers showed that 48 centers had a general policy with variable indications for autologous back-up harvest. Thirty-five patients with graft failure (25), GVHD (8) or relapse (2) retransplanted with autologous back-ups were reported. Autologous back-up transfusion was performed at a median of 35 days (patients with graft failure) or 90 days (patients with GVHD) after allogeneic HSCT. Within 100 days after autologous HSCT, 21 patients died from treatment-related complications (19) or relapse (2). Estimated overall survival at 1 year was 16% (95% CI 0-32%) for patients treated for graft failure and 13% (95% CI 0-37%) for GVHD patients. In conclusion, our data demonstrate that the indication for autologous back-up harvests is l...Continue Reading

References

Jul 25, 1998·Bone Marrow Transplantation·M RembergerJ Aschan
Jun 4, 2002·Nature Medicine·Takanori TeshimaJames L M Ferrara
Dec 10, 2003·Journal of Pediatric Hematology/oncology·Paul WoodardRupert Handgretinger
Oct 19, 2004·Bone Marrow Transplantation·J R PasswegJ Mehta
Sep 22, 2007·Blood Cells, Molecules & Diseases·Peter LangRupert Handgretinger

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Citations

May 8, 2009·Bone Marrow Transplantation·C StotlerE Copelan
Jun 11, 2014·Leukemia & Lymphoma·Christelle FerràUNKNOWN Grupo Español de Trasplante Hematopoyético (Geth) Spanish Society of Hematology
Feb 23, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jeffrey SchriberMarcelo C Pasquini

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