The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells

Gene
J M Higgins

Abstract

Haspin is a serine/threonine kinase, recently identified in mice, that is thought to regulate cell cycle and differentiation of haploid germ cells. Here, the haspin gene is identified within an intron of the integrin alphaE gene. Transcription occurs from a bi-directional CpG island-associated promoter that also generates an alternatively spliced integrin alphaE derived RNA. Remarkably, the human and murine haspin genes lack introns, and have features of retroposons. The human haspin cDNA reveals that the human and murine proteins are 83% identical in the C-terminal kinase domain, but only 53% identical in the N-terminal region. The haspin kinase domain has structural features that distinguish it from previously characterized proteins and suggest that haspin is a member of a new family of protein kinases. Although formerly thought to be expressed selectively in the testes, haspin is also transcribed at lower levels in thymus, bone marrow, fetal liver and other fetal tissues, and in all proliferating cell lines tested. Thus haspin is likely to be important in regulation of diploid as well as haploid cell differentiation in a variety of tissues.

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Citations

Dec 10, 2009·Chromosoma·Jonathan M G Higgins
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeyanthy EswaranStefan Knapp
Jul 27, 2001·Protein Science : a Publication of the Protein Society·J M Higgins
May 25, 2011·The Journal of Reproduction and Development·Shun SatoKunio Shiota
Jun 10, 2010·Bioorganic & Medicinal Chemistry Letters·Mayalen OxobyVincent Gerusz
Oct 25, 2017·International Journal of Molecular Sciences·Jong-Eun KimKi Won Lee
Aug 15, 2017·Chromosoma·Masashi HadaYuki Okada
Jan 10, 2018·Frontiers in Cell and Developmental Biology·Sanne HindriksenMichael A Hadders
Dec 14, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Hiromitsu TanakaJunhyeok Park
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Martina GalliMarco Muzi-Falconi
Oct 8, 2021·Scientific Reports·Katerina SoupsanaSpyros Georgatos

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