The hazards and risks of inhaled poorly soluble particles - where do we stand after 30 years of research?

Particle and Fibre Toxicology
Paul J A Borm, Kevin E Driscoll

Abstract

In 2006, titanium dioxide and carbon black were classified by IARC as "possibly carcinogenic to humans" and in 2017 the European Chemicals Agency's (ECHA) Committee for Risk Assessment concluded titanium dioxide meets the criteria to be classified as suspected of causing cancer (category 2, through the inhalation route). These classifications were based primarily on the occurrence of lung cancer in rats exposed chronically to high concentrations of these materials, as no such responses have been observed in other animal species similarly exposed. After the EU classification of titanium dioxide, it was suggested that Poorly Soluble particles of Low Toxicity (PSLTs) can be evaluated as a group. To better understand the current state of scientific opinion, we sought perspective from several international experts on topics relevant to the classification of carbon black; titanium dioxide; and, the potential future classification of PSLTs. Areas discussed included: grouping of PSLTs; the relevance of rat lung cancer responses to high concentrations of PSLTs; and, clearance overload and implications for interpretation of inhalation toxicology studies. We found there were several areas where a large majority of experts, including ourse...Continue Reading

References

Apr 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P E Morrow
Jun 30, 1985·Toxicology and Applied Pharmacology·K P LeeC F Reinhardt
Apr 1, 2004·International Journal of Cancer. Journal International Du Cancer·Paul J A BormCatrin Albrecht
Sep 18, 2012·Accounts of Chemical Research·Wolfgang G KreylingWinfried Möller

❮ Previous
Next ❯

Citations

Mar 10, 2020·Inhalation Toxicology·Kevin E Driscoll, Paul J A Borm
Jul 15, 2020·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Marie CarriereThierry Douki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.