Sep 1, 1990

The heart rate-PR interval relationship: a model for evaluating drug actions on SA and AV nodal function

British Journal of Clinical Pharmacology
W R Danter, S G Carruthers


The relationship between heart rate (HR) and PR interval (PR) has been investigated to determine inter-subject variability, within-subject variability and potential reference standards. Eight healthy male volunteers underwent upright graded submaximal treadmill exercise during eight separate study sessions. All subjects exhibited statistically significant negative linear relationships between PR and HR. Although there was considerable inter-subject variability, there was little within-subject variability in the interpolated PR at HR between 80 and 120 beats min-1. The HR-PR regression model has greatest validity within this HR range and for individual subjects rather than pooled or group data.

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Mentioned in this Paper

Sinoatrial Node
Human Volunteers
Exercise, Isometric
Pharmacologic Substance
Structure of Atrioventricular Node
NODAL gene
Heart Rate
Regression Analysis
Spontaneous Abortion
Pulse Rate

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