The heart rate variability-derived Newborn Infant Parasympathetic Evaluation (NIPE™) Index in pediatric surgical patients from 0 to 2 years under sevoflurane anesthesia-A prospective observational pilot study

Paediatric Anaesthesia
Frank WeberThomas G de Leeuw

Abstract

The heart rate variability-derived Newborn Infant Parasympathetic Evaluation (NIPE™) Index is a continuous noninvasive tool to assess pain and discomfort in infants <2 years. Initial studies focused on pain monitoring in the neonatal intensive care unit environment. The aim of this study was to investigate the performance of the NIPE in infants under sevoflurane anesthesia. The primary objective of this study was to compare the NIPE and heart rate as tools to help recognize the need for additional opioid drugs. Secondary objectives were the course of the NIPE and heart rate around specific standardized noxious procedural mile-stones. NIPE and heart rate values recorded during a 120 seconds interval before the anesthetist's decision to administer additional opioid due to the perceived insufficient antinociception and during a 120 seconds interval after drug administration were analyzed by means of a repeated measures ANOVA. The same analyses were performed for datasets around per protocol administration of morphine for postoperative analgesia, performance of a caudal block and surgical incision. In patients with a NIPE value <50, an additional opioid drug administration resulted in a rise of NIPE values, reaching a maximum incre...Continue Reading

References

Aug 6, 1999·British Journal of Anaesthesia·M Tanaka, T Nishikawa
Dec 28, 2002·Anesthesiology·Noriaki KanayaAkiyoshi Namiki
Oct 26, 2010·The Clinical Journal of Pain·Papa M FayeLaurent Storme
Sep 10, 2013·Best Practice & Research. Clinical Anaesthesiology·Matthias Gruenewald, Christoph Ilies
May 16, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sandra CardosoHercília Guimarães
Jun 20, 2017·Anesthesia and Analgesia·Georges DaccacheDominique Fletcher
Sep 25, 2017·Physiological Research·K JavorkaM Zibolen

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Citations

Aug 3, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Morgan RecherJulien De Jonckheere
Feb 17, 2021·Journal of Clinical Monitoring and Computing·Morgan RecherJulien De Jonckheere
Oct 20, 2020·Frontiers in Neuroscience·Marco ChieraAndrea Manzotti

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