PMID: 16634545Apr 26, 2006Paper

The heart rate variability in mice: telemetric evaluation of endotoxin shock

Masui. The Japanese journal of anesthesiology
Yushi AdachiShigehito Sato

Abstract

Recently, the knowledge regarding all types of shock has increased. In the critical period, the maintenance of perfusion to important organs and of autonomic cardiovascular control is a clue to improve outcome. The current investigation studied the effects of endotoxin shock on the heart rate variability (HRV), which might be an early marker of multiple organ dysfunction syntion. CL 57 BL/6 J mice (30-32 g) were implanted with intra-abdominal telemetry transmitters and data collection began 7 days after surgery and continued for 5 hours after the treatment. In endotoxin group, 3 mg x kg(-1) of E. coli lipopylysaccharide (0127 : B 8) was administered intraperitoneally and the same dose of saline was administered in control group. From the beat-by-beat values, heart rate (HR), standard deviation and coefficients of variation (RMSSD) were calculated. Integrated values of power spectral density were derived by summing depending on the frequency ranges, which were chosen with respect to the results of the previous investigation as follows: very low frequency (VLF) < 0.15 Hz; low frequency (LF), 0.15-1.5 Hz; and high frequency (HF), 1.5-5.0 Hz. HR showed no difference between the groups. RMSSD, Total Power, VLF, LF and HF increased i...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.