The heart tube forms and elongates through dynamic cell rearrangement coordinated with foregut extension

Development
Hinako KidokoroYukio Saijoh

Abstract

In the initiation of cardiogenesis, the heart primordia transform from bilateral flat sheets of mesoderm into an elongated midline tube. Here, we discover that this rapid architectural change is driven by actomyosin-based oriented cell rearrangement and resulting dynamic tissue reshaping (convergent extension, CE). By labeling clusters of cells spanning the entire heart primordia, we show that the heart primordia converge toward the midline to form a narrow tube, while extending perpendicularly to rapidly lengthen it. Our data for the first time visualize the process of early heart tube formation from both the medial (second) and lateral (first) heart fields, revealing that both fields form the early heart tube by essentially the same mechanism. Additionally, the adjacent endoderm coordinately forms the foregut through previously unrecognized movements that parallel those of the heart mesoderm and elongates by CE. In conclusion, our data illustrate how initially two-dimensional flat primordia rapidly change their shapes and construct the three-dimensional morphology of emerging organs in coordination with neighboring morphogenesis.

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Citations

May 10, 2019·Cell Cycle·Tara M Finegan, Dan T Bergstralh
Sep 12, 2019·Environmental Toxicology·Cho-Won KimKyung-Chul Choi
Nov 27, 2019·Cold Spring Harbor Perspectives in Biology·Johannes G Wittig, Andrea Münsterberg
Nov 24, 2018·Development·Audrey DesgrangeSigolène M Meilhac
Mar 14, 2019·Nature Communications·William Y WangBrendon M Baker
Nov 12, 2020·Cell Stem Cell·Giuliana RossiMatthias P Lutolf
Feb 14, 2021·Journal of Cardiovascular Development and Disease·Cassie L KemmlerChristian Mosimann
Feb 24, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Graham RykielSandra Rugonyi
Nov 25, 2020·Developmental Cell·Yukio Saijoh, Hiroshi Hamada
May 14, 2021·IScience·Hana KolesováDavid Sedmera

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