The Heartmate Risk Score predicts morbidity and mortality in unselected left ventricular assist device recipients and risk stratifies INTERMACS class 1 patients

JACC. Heart Failure
Luigi AdamoShane J LaRue

Abstract

This study evaluated the Heartmate Risk Score (HMRS) and its potential benefits in clinical practice. The HMRS has been shown to correlate with mortality in the cohort of patients enrolled in the Heartmate II trials, but its validity in unselected, "real world" populations remains unclear. This study identified a cohort of 269 consecutive patients who received a Heartmate II left ventricular assist device at our institution, the Barnes-Jewish Hospital in St. Louis, Missouri, between June 2005 and June 2013. Ninety-day and 2-year mortality rates, as well as frequency of several morbid events, were compared by retrospectively assigned HMRS category groups. The analysis was repeated within the subgroup of INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) class 1 patients. Receiver operating curve analysis showed that the HMRS correlated with 90-day mortality with an area under the curve of 0.70. Stratification in low, mid, and high HMRS groups identified patients with increasing hazard of 90-day mortality, increasing long-term mortality, increasing rate of gastrointestinal bleeding events, and increasing median number of days spent in the hospital in the first year post implant. Within INTERMACS class ...Continue Reading

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Citations

Mar 10, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jennifer Ann CowgerChristopher Salerno
Mar 26, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Anna Mara ScandroglioThomas Krabatsch
Mar 20, 2014·European Journal of Internal Medicine·Enrico AmmiratiMaria Frigerio
Nov 7, 2016·JACC. Heart Failure·Garrick C Stewart
Nov 8, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Koji TakedaHiroo Takayama
Dec 19, 2016·The Journal of Thoracic and Cardiovascular Surgery·Daisuke YoshiokaKoji Takeda
Jan 19, 2019·The International Journal of Artificial Organs·Edis LjajikjMichiel Morshuis
May 8, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·David S RaymerJustin M Vader
May 8, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Lauren K TrubyVeli K Topkara
Jan 29, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Manreet K KanwarJames F Antaki
May 16, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Javier Amione-GuerraBarry H Trachtenberg
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Sep 1, 2021·The Journal of Thoracic and Cardiovascular Surgery·Francesco Pollari, Michele Di Mauro

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