The hedgehog-related gene qua-1 is required for molting in Caenorhabditis elegans

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Limin HaoThomas R Bürglin

Abstract

The Caenorhabditis elegans genome encodes ten proteins that share similarity with Hedgehog through the C-terminal Hint/Hog domain. While most genes are members of larger gene families, qua-1 is a single copy gene. Here we show that orthologs of qua-1 exist in many nematodes, including Brugia malayi, which shared a common ancestor with C. elegans about 300 million years ago. The QUA-1 proteins contain an N-terminal domain, the Qua domain, that is highly conserved, but whose molecular function is not known. We have studied the expression pattern of qua-1 in C. elegans using a qua-1::GFP transcriptional fusion. qua-1 is mainly expressed in hyp1 to hyp11 hypodermal cells, but not in seam cells. It is also expressed in intestinal and rectal cells, sensilla support cells, and the P cell lineage in L1. The expression of qua-1::GFP undergoes cyclical changes during development in phase with the molting cycle. It accumulates prior to molting and disappears between molts. Disruption of the qua-1 gene function through an internal deletion that causes a frame shift with premature stop in the middle of the gene results in strong lethality. The animals arrest in the early larval stages due to defects in molting. Electron microscopy reveals d...Continue Reading

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Citations

Jan 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jörgen StenvallSimon Tuck
Nov 2, 2006·BMC Genomics·Limin HaoThomas R Bürglin
Nov 15, 2007·PloS One·Sanjay KumarClotilde K S Carlow
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mustapha Moussaif, Ji Ying Sze
Dec 21, 2006·Genetics·Samuel LiégeoisMichel Labouesse
Jul 2, 2014·Biochimica Et Biophysica Acta·Marta Kostrouchova, Zdenek Kostrouch
Feb 14, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Annabel ChristThomas E Willnow
Nov 1, 2006·Circulation·Maarten F BijlsmaC Arnold Spek
Oct 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Limor BrodayZe'ev Ronai
Mar 30, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Andrew D Chisholm, Suhong Xu
Nov 30, 2019·Genetics·Esther Serrano-SaizOliver Hobert
Oct 2, 2019·Journal of Developmental Biology·Emily A Baker, Alison Woollard
Jul 14, 2017·Worm·Vladimir Lažetić, David S Fay
Oct 17, 2019·Biochemical and Biophysical Research Communications·Masahiko KumeMasamitsu Fukuyama
Mar 3, 2021·BMC Ecology and Evolution·E A BakerA Woollard
Jan 1, 2020·Genetics·Esther Serrano-SaizOliver Hobert
Apr 27, 2007·Trends in Parasitology·Hannah CraigDarren R Brooks
Sep 14, 2011·Biochemical and Biophysical Research Communications·Nathaniel A KounsMarta Kostrouchova

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