PMID: 9160199Apr 1, 1997Paper

The Helicobacter pylori seroprevalence in blood donors related to Lewis (a,b) histo-blood group phenotype

European Journal of Gastroenterology & Hepatology
K KlaamasT Wadström

Abstract

To study a possible association of the Helicobacter pylori seroprevalence with ABO(H) and Lewis (a,b) blood group phenotypes in blood donors. A cross-sectional study of blood donors using ABO(H) and Lewis (a,b) blood group phenotype as predictors. ABO(H) and Lewis (a,b) blood group phenotyping was performed with monoclonal antibody. The H. pylori immunoglobulin G (IgG) antibody relative activity was evaluated by enzyme-linked immunosorbent assay (ELISA) using acid glycine extract from H. pylori. One hundred and fifty-nine randomly selected blood transfusion donors. The individuals with Lewis (a+b-)/non-secretor phenotype showed a significantly higher proportion of the H. pylori-seronegative subjects and a lower IgG immune response to H. pylori antigens as compared with the individuals of Lewis (a-b+)/secretor phenotype. The Lewis (a,b) histo-blood group antigens are implicated in the mechanisms of naturally occurring resistance to H. pylori infection.

Citations

Dec 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·F X WeillF Mégraud
Oct 13, 2000·Gastroenterology Clinics of North America·J E Everhart
Sep 21, 2000·European Journal of Biochemistry·D A RaskoD E Taylor
Oct 24, 1998·Molecular Microbiology·C C McGowanM J Blaser
Jan 16, 2013·International Journal of Cancer. Journal International Du Cancer·Cosmeri RizzatoFederico Canzian
Jun 19, 2015·Clinical Microbiology Reviews·Laura Cooling

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