PMID: 9171391Jun 1, 1997Paper

The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase

Journal of Bacteriology
H De ReuseD Mengin-Lecreulx

Abstract

The function of UreC, the product of a 1,335-bp-long open reading frame upstream from the urease structural genes (ureAB) of Helicobacter pylori, was investigated. We present data showing that the ureC gene product is a phosphoglucosamine mutase. D. Mengin-Lecreulx and J. van Heijenoort (J. Biol. Chem. 271:32-39, 1996) observed that UreC is similar (43% identity) to the GlmM protein of Escherichia coli. Those authors showed that GlmM is a phosphoglucosamine mutase catalyzing interconversion of glucosamine-6-phosphate into glucosamine-1-phosphate, which is subsequently transformed into UDP-N-acetylglucosamine. The latter product is one of the main cytoplasmic precursors of cell wall peptidoglycan and outer membrane lipopolysaccharides. The present paper reports that, like its E. coli homolog glmM, the H. pylori ureC gene is essential for cell growth. It was known that growth of a lethal conditional glmM mutant of E. coli at a nonpermissive temperature can be restored in the presence of the ureC gene. We showed that complete complementation of the glmM mutant can be obtained with a plasmid overproducing UreC. The peptidoglycan content and the specific phosphoglucosamine mutase activity of such a complemented strain were measured;...Continue Reading

References

Jan 1, 1986·Annual Review of Genetics·C R Raetz
Nov 15, 1973·Journal of Molecular Biology·U K Laemmli, M Favre
Jul 28, 1995·Science·R D FleischmannJ M Merrick
Jan 5, 1996·The Journal of Biological Chemistry·D Mengin-Lecreulx, J van Heijenoort
Apr 1, 1996·Alimentary Pharmacology & Therapeutics·H L Mobley

❮ Previous
Next ❯

Citations

Feb 13, 1999·Molecular Microbiology·D KersulyteD E Berg
May 7, 1999·European Journal of Biochemistry·L JollyD Mengin-Lecreulx
Nov 5, 1999·Annual Review of Microbiology·Z Ge, D E Taylor
Dec 25, 2009·Current Microbiology·Emanuela Di CampliLuigina Cellini
Nov 26, 2010·Critical Reviews in Biotechnology·Ankur GautamRupinder Tewari
Jun 16, 2015·Frontiers in Public Health·Mahnaz Mazaheri AssadiAnwar Huq
Jul 9, 2004·Journal of Applied Microbiology·L CelliniG Donelli
Sep 15, 2011·Revista Do Instituto De Medicina Tropical De São Paulo·Rito PolancoMonica Contreras
Feb 4, 2011·Journal of Clinical Microbiology·Maria Guadalupe Córdova EspinozaSilvia Giono Cerezo
Sep 9, 2009·Expert Review of Anti-infective Therapy·Megan J DuckworthGeorge L Mendz
Oct 6, 2007·Scandinavian Journal of Gastroenterology·Luigina CelliniRoberto Lattanzio
Jul 8, 2011·Journal of Clinical Microbiology·Amin Talebi Bezmin AbadiD Scott Merrell
Jul 20, 2011·The FEBS Journal·Ritcha Mehra-ChaudharyLesa J Beamer
Jan 25, 2018·International Journal of Molecular Sciences·Natalja ŠebunovaReet Mändar
Oct 4, 2014·World Journal of Gastroenterology : WJG·Saurabh Kumar PatelGopal Nath
Feb 15, 2000·Journal of Bacteriology·L JollyD Mengin-Lecreulx
Jul 27, 2002·Journal of Bacteriology·Christophe H SchillingBernhard O Palsson
Apr 13, 2007·Clinical Microbiology Reviews·Francis Mégraud, Philippe Lehours
Jul 21, 2020·Helicobacter·Fatimetou KhiddiNabil Gastli
Jul 27, 2000·Journal of Bacteriology·I M TavaresD Mengin-Lecreulx
Jan 29, 2021·Journal of Infection and Public Health·Saori HoriuchiHisakazu Yano
Apr 10, 1999·Journal of Bacteriology·D J McGeeH L Mobley
Apr 27, 2021·Critical Reviews in Microbiology·Xiaojun MaoFabian Cieplik
Apr 9, 2005·Journal of Clinical Microbiology·Farhana KauserNiyaz Ahmed
Feb 13, 1999·Journal of Clinical Microbiology·J J LuC H Lee
Mar 22, 2001·Archives of Pathology & Laboratory Medicine·J A PeñaJ Versalovic
May 24, 2008·Environmental Science & Technology·Yoshiko FujitaRobert W Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.