PMID: 11325471Apr 28, 2001Paper

The hemagglutinin-neuraminidase protein of peste des petits ruminants virus is biologically active when transiently expressed in mammalian cells

Virus Research
Shaguna Seth, M S Shaila

Abstract

The genes coding for the surface glycoproteins hemagglutinin-neuraminidase (HN) of the peste des petits ruminants virus (PPRV) and hemagglutinin (H) of rinderpest virus (RPV) were cloned in a cytomagalovirus promoter driven expression vector and expressed transiently in mammalian cells. The protein expression was apparent 24 h after transfection and the expressed proteins were detected at the cell surface. The transiently expressed PPRV HN protein was found to be biologically active in possessing hemadsorption and neuraminidase activities. On the other hand, RPV H protein exhibited neuraminidase activity but was deficient in hemadsorption activity. The substrate specificity of the neuraminidase activity of these two proteins differed distinctly. The presence of neuraminidase activity in both PPRV HN and RPV H proteins is unusual among members of the morbillivirus genus.

References

Feb 1, 1991·The Journal of General Virology·T F WildR Buckland
Jun 3, 1989·The Veterinary Record·F A AtaA A Ata
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R G PatersonR A Lamb
Feb 1, 1984·The Journal of General Virology·T M VarsanyiE Norrby
Jan 1, 1980·Reviews of Infectious Diseases·P W Choppin, A Scheid
Feb 9, 1957·Nature·W PLOWRIGHT, R D FERRIS

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Citations

Sep 17, 2014·Veterinary Research Communications·Fuxiao LiuZhiliang Wang
Jul 14, 2010·Expert Review of Vaccines·Arnab SenRaj Kumar Singh
Jan 31, 2020·Acta Veterinaria Scandinavica·Edson KinimiGerald Misinzo

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