PMID: 9549563Apr 29, 1998Paper

The hematological responses of rats exposed to conditions of simulated microgravity and acute exercise

Aviation, Space, and Environmental Medicine
C M TiptonL A Sebastian

Abstract

Although humans have experienced microgravity since 1961, it is unknown whether PaO2 or PaCO2 will change in humans or in animals exposed to similar conditions. Reports from subjects participating in long-term head down tilt studies indicate that PAO2 will decrease and PaCO2 will increase, presumably because of impairments in oxygen delivery and carbon dioxide transport. To investigate this topic with suspended (HDS) rats, we hypothesized that 14 d of HDS would lower resting PaO2 and elevate PaCO2 pressures when compared with control rats. Since returning astronauts, previously bed rested subjects, and suspended rats had exhibited decreases in maximum aerobic capacity, we predicted after 2 weeks of HDS, rats performing maximum exercise would demonstrate significant decreases in PaO2 and elevations in hydrogen ions. Blood gas results during HDS indicated PaO2 and PaCO2 partial pressures were significantly decreased during the first week of suspension. Maximal exercise significantly increased PaO2 pressures in both animal groups, but during exercise the suspended rats exhibited significant increases in lactic acid and hydrogen ion concentrations when compared with control animals. The suspended rat model effectively characterized...Continue Reading

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
C M TiptonM M Moran
© 2022 Meta ULC. All rights reserved