The hematopoietic stem cell niche: What's so special about bone?

Bone
Benjamin J Frisch

Abstract

Hematopoietic stem cells (HSCs) require a supportive microenvironment to regulate their function and produce sufficient hematopoietic cells over the lifetime of an individual. With the exception of fish, all vertebrates, including mammals, maintain HSCs in a complex niche within the bone marrow. Several bone specific cellular populations have been implicated as components of the HSC niche and are part of a complex network that regulates HSC functions. However, the full extent of interactions within the HSC niche, and the role of individual cell populations remain to be fully elucidated. Further, it is not clear why fish are the exception, and what advantage is gained by housing HSCs in the bone marrow. To gain a better understanding of hematopoiesis and the mechanisms that drive hematopoietic disease processes a clearer picture of the complex HSC regulatory interactions in the bone marrow microenvironment is required.

Citations

Nov 27, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jaime FornettiSheila A Stewart
Jul 23, 2019·International Journal of Radiation Biology·Laura M CalviJames Palis
May 16, 2019·The Journal of Clinical Investigation·Darja KarpovaJohn F DiPersio
Mar 5, 2019·The Journal of Clinical Investigation·Stefania CrippaMaria Ester Bernardo
Oct 21, 2020·Leukemia·Stephanie N HurwitzPeter Kurre
Mar 23, 2021·Acta Biomaterialia·Sheng Yin, Yi Cao
May 13, 2021·Cell and Tissue Research·Genilza Pereira de OliveiraAlessandra Alves Thole
Jul 31, 2020·Current Stem Cell Research & Therapy·Chinwe OkekeChiedozie Chikwendu

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