PMID: 7932795Apr 1, 1994Paper

The hemispheric cerebrovascular response to hemodilution is attenuated by a focal cryogenic brain injury

Journal of Neurotrauma
M M ToddD S Warner

Abstract

Experimental brain injury attenuates the normal increase in cerebral blood flow (CBF) that accompanies a fall in PaO2, and this may contribute to the well-known detrimental effects of hypoxia following closed head injury. Anemia is also known to adversely affect posttraumatic survival, and it is reasonable to hypothesize that this too may be related to an altered cerebrovascular response. Therefore, to examine this possibility, pentobarbital-anesthetized rabbits were subjected to a left posterior parietal cryogenic cortical injury, followed 90 min later by isovolemic hemodilution with hetastarch. Unlesioned control animals underwent an identical degree of hemodilution. CBF was measured using radioactive microspheres. In control animals, hemodilution was accompanied by a marked increase in CBF in all brain regions. For example, in the left posterior cortex, CBF increased from 30 +/- 14 mL/100 g/min (baseline Hct = 42 +/- 2%, mean +/- SD) to 100 +/- 20 mL/100 g/min at Hct = 12 +/- 1%. By contrast, there was a markedly attenuated response throughout the left (ipsilateral) hemisphere of injured animals, even in cortical regions distant from the injury. For example, in the left posterior cortex, CBF changed from a baseline of 32 +/-...Continue Reading

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Citations

Oct 20, 2010·Journal of Neurotrauma·Garth H UtterJ Paul Muizelaar
Jun 13, 2009·Critical Care : the Official Journal of the Critical Care Forum·Andreas H Kramer, David A Zygun
Apr 20, 2010·Critical Care : the Official Journal of the Critical Care Forum·Jennifer DiedlerThorsten Steiner
Feb 9, 2012·Current Treatment Options in Neurology·Andreas H Kramer, Peter Le Roux
Sep 27, 2015·Current Treatment Options in Neurology·G Duemani ReddyClaudia S Robertson
Aug 9, 2002·Anesthesiology Clinics of North America·Concezione Tommasino
Mar 19, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yi-Jun ZengYong-Jun Wang
Jul 14, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C LenzK F Waschke
Aug 3, 2016·Acta Neurologica Scandinavica·G KaiafaA I Hatzitolios

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