The Hemodynamic Response of Spreading Depolarization Observed by Near Infrared Spectroscopy After Aneurysmal Subarachnoid Hemorrhage

Neurocritical Care
Martin SeuleOliver W Sakowitz

Abstract

Electrocorticography (ECoG) in brain-injured patients allows to detect spreading depolarization, a potential mechanism of secondary ischemia. Here, we describe the relationship of spreading depolarization with changes in cerebral hemodynamics using a brain tissue probe applying near infrared spectroscopy (NIRS). Simultaneous ECoG and NIRS monitoring was performed in a patient with severe aneurysmal subarachnoid hemorrhage. Changes in cerebral blood oxygenation and regional cerebral blood volume were studied before and after the occurrence of spreading depolarization. Cerebral blood flow measurements were performed daily using an indocyanine green dye dilution mode. Single events of spreading depolarizations demonstrated with transient hyperoxic responses and increase in cerebral blood volume. On the other hand, temporal clusters of recurrent spreading depolarizations were associated with prolonged hypoxic responses and decrease in cerebral blood volume. Cerebral blood flow measurements showed higher values before compared to after onset of spreading depolarization (33.7 ± 8.4 vs. 24.2 ± 4.5 ml/100 g/min). The findings suggest that NIRS monitoring in the cerebral white matter might reflect the hemodynamic signature of spreading ...Continue Reading

References

Feb 1, 1994·Brain : a Journal of Neurology·M Lauritzen
Sep 18, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P DreierU Dirnagl
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Anthony J StrongMartin Lauritzen
Dec 13, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hwa Kyoung ShinCenk Ayata
Dec 21, 2005·Brain : a Journal of Neurology·Martin FabriciusMartin Lauritzen
Apr 18, 2007·Brain : a Journal of Neurology·Anthony J StrongRudolf Graf
May 4, 2010·Annals of Neurology·Bert BoscheUNKNOWN Members of the Cooperative Study of Brain Injury Depolarizations (COSBID)
Dec 12, 2012·Stroke; a Journal of Cerebral Circulation·Oliver W SakowitzAsita S Sarrafzadeh

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Citations

Jun 19, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jens P DreierJed A Hartings
May 22, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Raimund HelbokMartin Fabricius
Mar 31, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maren Kl WinklerJens P Dreier
Apr 25, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alois J SchiefeckerRaimund Helbok
Jun 4, 2016·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Pierre BouzatFabio S Taccone
Jan 27, 2017·Neural Regeneration Research·Ping-Ping ShenJia-Chun Feng
Oct 24, 2017·Human Brain Mapping·Ali KassabDang Khoa Nguyen
Apr 24, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kazutaka Sugimoto, David Y Chung
Jun 19, 2019·Scientific Reports·Thomas KirchnerLena Maier-Hein
Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Andrea Jaquins-Gerstl, Adrian C Michael
Feb 27, 2021·The American Journal of Pathology·Katharina Eikermann-Haerter, Susie Y Huang
Jun 28, 2019·ACS Chemical Neuroscience·Elaine M RobbinsAdrian C Michael

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