The hemodynamic response to blood loss in the conscious rat: contributions of cardiac vagal and cardiac spinal signals

Shock
B P TroyK A Keay

Abstract

The hemodynamic response to progressive blood loss passes through three distinct phases: an initial normotensive compensatory phase, a secondary hypotensive decompensatory phase, and a posthemorrhage recompensatory phase. The role of cardiac vagal and cardiac spinal signals in triggering the different phases of the response to hemorrhage was evaluated in the unanesthetized, freely moving rat by observing the effects on the response to 30% blood loss of prior cardiac vagal deafferentation (bilateral vagal rhizotomy) or prior cardiac spinal deafferentation (bilateral stellate ganglionectomy). In comparison to control animals, it was found that (i) cardiac spinal deafferentation significantly delayed the onset of the decompensatory phase, and (ii) cardiac vagal deafferentation slightly potentiated the decompensatory phase and impaired the recompensatory phase. These results indicate that it is cardiac spinal signals, rather than cardiac vagal signals, which in the conscious rat contribute to the triggering and progression of the decompensatory response to blood loss.

References

Nov 25, 1977·Pflügers Archiv : European journal of physiology·K NishiF Takenaka
Jul 1, 1991·Physiological Reviews·R Hainsworth
Dec 1, 1985·Acta Physiologica Scandinavica·P SkoogP Thorén
Jan 1, 1989·The Japanese Journal of Physiology·P PalB Koley
Nov 1, 1986·Journal of Applied Physiology·D BerryA Jobe
Mar 1, 1983·Journal of the Autonomic Nervous System·A MallianiS Guzzetti
Oct 1, 1982·Circulation·B FreedmanD T Kelly
May 1, 1994·Clinical and Experimental Pharmacology & Physiology·D W BlakeO U Petring
Apr 1, 1993·Journal of the American College of Cardiology·A P FitzpatrickR Sutton
Jan 9, 1997·Brain Research·C Vayssettes-CourchayT J Verbeuren
Jun 29, 2001·Clinical and Experimental Pharmacology & Physiology·R G EvansJ Ludbrook
Nov 15, 2003·Autonomic Neuroscience : Basic & Clinical·B P TroyK A Keay

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