Abstract
A haematology analyser, based on a new technology, is presented herein. The analyser that provides a complete blood count (CBC) and five-part differential accepts disposable cartridges containing all required reagents, making it maintenance-free and ideal for point-of-care (POC) settings. The test reproducibility and imperviousness to analytical errors are attributed to the imaging-based analysis employed. Imaging enables cell-morphology-based differentiation, which is analogous to the gold standard microscopic analysis. This article presents the HemoScreen new technology and evaluates its performance through a small-scale study conducted in its designated clinical settings. Thirty anticoagulated whole blood samples were analysed on the HemoScreen and Sysmex XE-2100. Linear regression was performed for the methods comparison. Two samples with 15 replicates were processed for imprecision. Ease of use of the device was also considered. The HemoScreen demonstrated acceptable imprecision and good agreement with the Sysmex XE-2100. The white blood cells (WBCs), red blood cells (RBCs), haemoglobin (HGB), haematocrit (HCT), platelets (PLT), neutrophils, lymphocytes and eosinophils have coefficients of correlation (r) >0.97. For mean c...Continue Reading
References
Jul 6, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mauro Buttarello
Aug 7, 2007·Physical Review Letters·A M LeshanskyU Dinnar
Jan 12, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·L V RaoMichael Snyder
Jun 14, 2008·American Journal of Clinical Pathology·Mauro Buttarello, Mario Plebani
Dec 4, 2008·Clinical Pediatrics·Janet R Casey, Michael E Pichichero
May 17, 2011·American Journal of Clinical Pathology·Brent T TanTracy I George
Mar 20, 2012·Lab on a Chip·Gaetano D'AvinoPier Luca Maffettone
Apr 19, 2013·American Journal of Clinical Pathology·Lisa MeintkerStefan W Krause
Jul 3, 2013·British Journal of Haematology·Peter Schuff-WernerPeter Kohlschein
Jul 31, 2013·British Journal of Biomedical Science·O ErhaborP Kinsella
Sep 24, 2013·Lab on a Chip·Francesco Del GiudicePier Luca Maffettone
Aug 12, 2014·BMJ Open·Jeremy HowickMatthew Thompson
Feb 14, 2015·Clinics in Laboratory Medicine·Lydie Da Costa
Citations
Mar 24, 2017·The Journal of Trauma and Acute Care Surgery·Michael A MeledeoAndrew P Cap
Oct 7, 2017·International Journal of Laboratory Hematology·N GraindorD Kieffer
Mar 3, 2017·Journal of Biomedical Optics·Amy J PowlessTimothy J Muldoon
Jun 9, 2019·BMC Family Practice·Anders LarssonMiklos Lipcsey
May 2, 2020·Electrophoresis·Jianke LuoQing Li
Nov 22, 2016·Biomedical Optics Express·Adel ZeidanDvir Yelin
Sep 8, 2020·International Journal of Laboratory Hematology·Dår Kristian KurLennart Friis-Hansen
Apr 13, 2019·Analytical and Bioanalytical Chemistry·Xinyi LiTingjuan Gao
Jul 9, 2017·Journal of Biophotonics·Dengling XieZachary J Smith
Dec 29, 2018·Platelets·Anders LarssonMiklos Lipcsey
Nov 3, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Oliver Hayden, Christian Klenk
Apr 1, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Arne ÅsbergUnn Merete Fagerli
Jul 16, 2021·American Journal of Hematology·Neta BacharCarlo Brugnara
Sep 25, 2021·Clinical Chemistry·Daniel S HermanThomas J S Durant